======= TIPRL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIPRL
  * **<color #00a2e8>Official Name</color>**: TOR signaling pathway regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=261726|261726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75663|O75663]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIPRL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIPRL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611807|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIP41|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TOR signaling|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|DNA damage checkpoint|
|regulation of protein dephosphorylation|
|DNA integrity checkpoint|
|regulation of phosphatase activity|
|cell cycle checkpoint|
|regulation of dephosphorylation|
|negative regulation of hydrolase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|regulation of hydrolase activity|
|intracellular signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.34|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.01|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.98|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.83|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.8|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.82|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.83|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.85|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.01|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.04|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.05|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.06|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.1|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.12|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.2|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.36|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.5|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.57|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.83|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.85|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.37|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|3.65|
|[[:results:exp59|UMK57 1μM R01 exp59]]|4.15|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|4.51|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|5.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp2r4|PPP2R4]]|0.682|
|[[:human genes:l:lcmt1|LCMT1]]|0.604|
|[[:human genes:p:ppme1|PPME1]]|0.559|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.474|
|[[:human genes:p:ppp6r3|PPP6R3]]|0.448|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIPRL Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>