======= TLK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLK2
  * **<color #00a2e8>Official Name</color>**: tousled like kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11011|11011]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UE8|Q86UE8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608439|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chromatin assembly or disassembly|
|cellular response to gamma radiation|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of ubiquitin-dependent protein catabolic process|
|response to gamma radiation|
|negative regulation of proteasomal protein catabolic process|
|cellular response to ionizing radiation|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of autophagy|
|negative regulation of cellular protein catabolic process|
|intermediate filament|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|response to ionizing radiation|
|regulation of ubiquitin-dependent protein catabolic process|
|cellular response to radiation|
|peptidyl-serine phosphorylation|
|regulation of proteasomal protein catabolic process|
|regulation of chromatin organization|
|peptidyl-serine modification|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|chromosome segregation|
|negative regulation of catabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of autophagy|
|regulation of chromosome organization|
|negative regulation of proteolysis|
|protein serine/threonine kinase activity|
|regulation of protein catabolic process|
|response to radiation|
|perinuclear region of cytoplasm|
|chromatin organization|
|regulation of proteolysis|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|intracellular signal transduction|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.42|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.24|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.9|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.79|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.78|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.7|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.74|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.76|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.05|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|3.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7967
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLK2 Expression in NALM6 Cells: 5.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>