======= TLR3 =======
== Gene Information ==
* **Official Symbol**: TLR3
* **Official Name**: toll like receptor 3
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7098|7098]]
* **UniProt**: [[https://www.uniprot.org/uniprot/O15455|O15455]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=TLR3&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR3|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/603029|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
|TIR|
|LRR 4|
|positive regulation of type III interferon production|
|regulation of type III interferon production|
|positive regulation of interferon-alpha biosynthetic process|
|detection of virus|
|necroptotic signaling pathway|
|regulation of interferon-alpha biosynthetic process|
|positive regulation of interferon-beta biosynthetic process|
|negative regulation of MyD88-independent toll-like receptor signaling pathway|
|regulation of interferon-beta biosynthetic process|
|regulation of MyD88-independent toll-like receptor signaling pathway|
|toll-like receptor 3 signaling pathway|
|regulation of dendritic cell cytokine production|
|I-kappaB phosphorylation|
|positive regulation of chemokine biosynthetic process|
|positive regulation of interferon-gamma biosynthetic process|
|endolysosome membrane|
|regulation of chemokine biosynthetic process|
|cellular response to exogenous dsRNA|
|regulation of interferon-gamma biosynthetic process|
|activation of NF-kappaB-inducing kinase activity|
|cellular response to interferon-beta|
|cellular response to dsRNA|
|positive regulation of toll-like receptor signaling pathway|
|necroptotic process|
|positive regulation of interferon-alpha production|
|hyperosmotic response|
|negative regulation of osteoclast differentiation|
|response to interferon-beta|
|programmed necrotic cell death|
|regulation of interferon-alpha production|
|TRIF-dependent toll-like receptor signaling pathway|
|necrotic cell death|
|leukocyte activation involved in inflammatory response|
|positive regulation of interferon-beta production|
|microglial cell activation|
|MyD88-independent toll-like receptor signaling pathway|
|positive regulation of interleukin-12 production|
|glial cell activation|
|negative regulation of toll-like receptor signaling pathway|
|neuroinflammatory response|
|response to exogenous dsRNA|
|negative regulation of myeloid leukocyte differentiation|
|regulation of interferon-beta production|
|positive regulation of interleukin-8 production|
|macrophage activation|
|response to dsRNA|
|regulation of interleukin-12 production|
|positive regulation of chemokine production|
|positive regulation of interferon-gamma production|
|regulation of osteoclast differentiation|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|double-stranded RNA binding|
|negative regulation of myeloid cell differentiation|
|response to osmotic stress|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of type I interferon production|
|regulation of chemokine production|
|cellular response to mechanical stimulus|
|NIK/NF-kappaB signaling|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|extrinsic apoptotic signaling pathway|
|toll-like receptor signaling pathway|
|regulation of interferon-gamma production|
|negative regulation of leukocyte differentiation|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|regulation of myeloid leukocyte differentiation|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|transmembrane signaling receptor activity|
|negative regulation of hemopoiesis|
|positive regulation of JNK cascade|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of tumor necrosis factor production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|male sex differentiation|
|cellular response to interferon-gamma|
|positive regulation of angiogenesis|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|response to interferon-gamma|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|defense response to virus|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|gonad development|
|endosome membrane|
|response to mechanical stimulus|
|development of primary sexual characteristics|
|regulation of myeloid cell differentiation|
|extracellular matrix|
|innate immune response-activating signal transduction|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|early endosome|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|regulation of leukocyte differentiation|
|response to virus|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|lysosomal membrane|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of vasculature development|
|activation of protein kinase activity|
|defense response to bacterium|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|cellular response to drug|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cell surface|
|Golgi membrane|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|positive regulation of immune response|
|regulation of kinase activity|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|defense response to other organism|
|protein phosphorylation|
|regulation of transferase activity|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 8434
* **Expression level (log2 read counts)**: 3.53
{{:chemogenomics:nalm6 dist.png?nolink |}}