======= TLR6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLR6
  * **<color #00a2e8>Official Name</color>**: toll like receptor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10333|10333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2C9|Q9Y2C9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLR6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605403|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid- beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B- dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor 6 signaling pathway|
|Toll-like receptor 2-Toll-like receptor 6 protein complex|
|detection of diacyl bacterial lipopeptide|
|Toll-like receptor 2 binding|
|detection of bacterial lipopeptide|
|toll-like receptor TLR6:TLR2 signaling pathway|
|cellular response to diacyl bacterial lipopeptide|
|detection of bacterial lipoprotein|
|response to diacyl bacterial lipopeptide|
|positive regulation of oxidative stress-induced neuron death|
|negative regulation of toll-like receptor 2 signaling pathway|
|cellular response to bacterial lipoprotein|
|cellular response to bacterial lipopeptide|
|response to bacterial lipopeptide|
|response to bacterial lipoprotein|
|positive regulation of NLRP3 inflammasome complex assembly|
|negative regulation of interleukin-8 secretion|
|lipopeptide binding|
|interleukin-1 beta secretion|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|regulation of toll-like receptor 2 signaling pathway|
|interleukin-1 secretion|
|detection of molecule of bacterial origin|
|detection of bacterium|
|detection of other organism|
|regulation of NLRP3 inflammasome complex assembly|
|positive regulation of oxidative stress-induced cell death|
|positive regulation of interleukin-6 biosynthetic process|
|interleukin-1 beta production|
|interleukin-1 production|
|positive regulation of cellular response to oxidative stress|
|nitric oxide metabolic process|
|activation of NF-kappaB-inducing kinase activity|
|negative regulation of interleukin-8 production|
|positive regulation of cytokine production involved in inflammatory response|
|detection of external biotic stimulus|
|positive regulation of response to oxidative stress|
|reactive nitrogen species metabolic process|
|regulation of interleukin-6 biosynthetic process|
|detection of biotic stimulus|
|regulation of interleukin-8 secretion|
|positive regulation of macrophage activation|
|regulation of oxidative stress-induced neuron death|
|response to lipoprotein particle|
|TRIF-dependent toll-like receptor signaling pathway|
|cellular response to lipoprotein particle stimulus|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|MyD88-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|glial cell activation|
|cellular response to amyloid-beta|
|positive regulation of nitric oxide biosynthetic process|
|negative regulation of toll-like receptor signaling pathway|
|positive regulation of nitric oxide metabolic process|
|regulation of cytokine production involved in inflammatory response|
|neuroinflammatory response|
|cytokine secretion|
|response to amyloid-beta|
|macrophage activation|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of macrophage activation|
|regulation of nitric oxide biosynthetic process|
|regulation of oxidative stress-induced cell death|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|negative regulation of cytokine secretion|
|regulation of interleukin-8 production|
|positive regulation of JUN kinase activity|
|phagocytic vesicle membrane|
|regulation of cellular response to oxidative stress|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|amyloid-beta binding|
|cell|
|regulation of response to oxidative stress|
|regulation of reactive oxygen species biosynthetic process|
|regulation of JUN kinase activity|
|neurotransmitter metabolic process|
|positive regulation of neuron death|
|positive regulation of interleukin-6 production|
|positive regulation of reactive oxygen species metabolic process|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|reactive oxygen species metabolic process|
|pattern recognition receptor signaling pathway|
|negative regulation of protein secretion|
|transmembrane signaling receptor activity|
|negative regulation of peptide secretion|
|positive regulation of inflammatory response|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|peptide secretion|
|regulation of reactive oxygen species metabolic process|
|negative regulation of protein transport|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|cellular response to molecule of bacterial origin|
|negative regulation of secretion by cell|
|signaling receptor activity|
|regulation of cytokine secretion|
|receptor complex|
|cellular response to biotic stimulus|
|membrane raft|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of protein complex assembly|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|negative regulation of cytokine production|
|regulation of neuron death|
|response to molecule of bacterial origin|
|cellular response to peptide|
|activation of protein kinase activity|
|defense response to bacterium|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|regulation of neurotransmitter levels|
|positive regulation of response to biotic stimulus|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|regulation of protein secretion|
|response to peptide|
|positive regulation of defense response|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of peptide secretion|
|inflammatory response|
|drug metabolic process|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|detection of chemical stimulus|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of secretion|
|positive regulation of immune response|
|regulation of kinase activity|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|Golgi apparatus|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.85|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.88|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLR6 Expression in NALM6 Cells: 3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>