======= TM9SF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TM9SF4
  * **<color #00a2e8>Official Name</color>**: transmembrane 9 superfamily member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9777|9777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92544|Q92544]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TM9SF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TM9SF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617727|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). {ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576, ECO:0000269|PubMed:25999474}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EMP70|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase complex assembly|
|proton-transporting V-type ATPase complex assembly|
|proton-transporting two-sector ATPase complex assembly|
|positive regulation of protein exit from endoplasmic reticulum|
|positive regulation of protein localization to cell surface|
|regulation of protein exit from endoplasmic reticulum|
|regulation of protein localization to cell surface|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|early endosome|
|positive regulation of cellular protein localization|
|phagocytosis|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|response to oxygen levels|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|regulation of cellular protein localization|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|ion homeostasis|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|chemical homeostasis|
|response to abiotic stimulus|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.6|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.42|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.61|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.97|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TM9SF4 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>