======= TMC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMC8
  * **<color #00a2e8>Official Name</color>**: transmembrane channel like 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=147138|147138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IU68|Q8IU68]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605829|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable ion channel. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TMC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mechanosensitive ion channel activity|
|negative regulation of protein oligomerization|
|ion channel activity|
|zinc ion homeostasis|
|regulation of protein oligomerization|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of protein binding|
|transition metal ion homeostasis|
|negative regulation of protein complex assembly|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of binding|
|regulation of protein binding|
|nuclear membrane|
|signaling receptor binding|
|regulation of binding|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|regulation of protein complex assembly|
|divalent inorganic cation homeostasis|
|metal ion homeostasis|
|regulation of growth|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|endoplasmic reticulum|
|chemical homeostasis|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.76|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMC8 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>