======= TMED2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMED2
  * **<color #00a2e8>Official Name</color>**: transmembrane p24 trafficking protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10959|10959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15363|Q15363]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMED2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMED2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. {ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:17693410, ECO:0000269|PubMed:20361938, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EMP24 GP25L|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI-coated vesicle membrane|
|Golgi transport vesicle coating|
|COPI-coated vesicle budding|
|COPI coating of Golgi vesicle|
|COPI-coated vesicle|
|somite rostral/caudal axis specification|
|zymogen granule membrane|
|labyrinthine layer blood vessel development|
|post-anal tail morphogenesis|
|vesicle cargo loading|
|placenta blood vessel development|
|maternal placenta development|
|embryonic axis specification|
|COPII-coated ER to Golgi transport vesicle|
|labyrinthine layer development|
|negative regulation of GTPase activity|
|anterior/posterior axis specification|
|ER to Golgi transport vesicle membrane|
|heart looping|
|embryonic pattern specification|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|maternal process involved in female pregnancy|
|somitogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|endoplasmic reticulum-Golgi intermediate compartment|
|embryonic heart tube development|
|Golgi vesicle budding|
|somite development|
|multicellular organism growth|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|axis specification|
|embryonic placenta development|
|vesicle targeting|
|neural tube closure|
|transport vesicle|
|tube closure|
|Golgi cisterna membrane|
|segmentation|
|vesicle budding from membrane|
|primary neural tube formation|
|neural tube formation|
|determination of left/right symmetry|
|embryonic epithelial tube formation|
|determination of bilateral symmetry|
|specification of symmetry|
|epithelial tube formation|
|Golgi organization|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|neural tube development|
|establishment of vesicle localization|
|female pregnancy|
|protein localization to plasma membrane|
|vesicle localization|
|multi-multicellular organism process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|anterior/posterior pattern specification|
|protein localization to cell periphery|
|heart morphogenesis|
|embryonic organ morphogenesis|
|vesicle organization|
|epithelial tube morphogenesis|
|regionalization|
|establishment of organelle localization|
|Golgi vesicle transport|
|in utero embryonic development|
|developmental growth|
|growth|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of hydrolase activity|
|protein localization to membrane|
|regulation of GTPase activity|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|organelle localization|
|Golgi membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|embryo development|
|Golgi apparatus|
|multi-organism reproductive process|
|intracellular protein transport|
|endoplasmic reticulum|
|epithelium development|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.28|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.16|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.98|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.71|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.71|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.7|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.75|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.77|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.93|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.07|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.16|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.23|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.24|
|[[:results:exp539|42°C R08 exp539]]|2.25|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.28|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.39|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.42|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmed10|TMED10]]|0.611|
|[[:human genes:s:sec31a|SEC31A]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 230/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|5/28|
|bone|7/26|
|breast|6/33|
|central nervous system|22/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|9/21|
|liver|8/20|
|lung|17/75|
|lymphocyte|7/16|
|ovary|11/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1979
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMED2 Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>