======= TMEM108 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM108
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 108
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=66000|66000]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXF1|Q6UXF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM108&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM108|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617361|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF- dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. {ECO:0000250|UniProtKB:Q8BHE4}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neurotrophin TRK receptor signaling pathway|
|cellular response to brain-derived neurotrophic factor stimulus|
|dendrite extension|
|somatodendritic compartment|
|regulation of neurotrophin TRK receptor signaling pathway|
|dentate gyrus development|
|postsynaptic density organization|
|retrograde axonal transport|
|postsynaptic specialization organization|
|modulation of excitatory postsynaptic potential|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|axonal transport|
|axon cytoplasm|
|neuron projection extension|
|axo-dendritic transport|
|hippocampus development|
|postsynapse organization|
|developmental cell growth|
|cell growth|
|limbic system development|
|developmental growth involved in morphogenesis|
|regulation of nervous system process|
|transport along microtubule|
|pallium development|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|postsynaptic membrane|
|endosome membrane|
|receptor-mediated endocytosis|
|postsynaptic density|
|early endosome|
|telencephalon development|
|synapse organization|
|microtubule-based movement|
|regulation of cellular response to growth factor stimulus|
|axon|
|forebrain development|
|developmental growth|
|growth|
|dendrite|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cellular component|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|cell junction|
|endocytosis|
|regulation of system process|
|neuron projection development|
|microtubule-based process|
|import into cell|
|cell morphogenesis|
|brain development|
|molecular function|
|head development|
|neuron development|
|cellular component morphogenesis|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.83|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.9|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6879
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM108 Expression in NALM6 Cells: 1.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>