======= TMEM114 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM114
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 114
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283953|283953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/B3SHH9|B3SHH9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM114&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM114|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

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No Pfam Domain information is available for this gene.
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<modal id='GO_terms' size='lg' title='GO Terms'>
|apicolateral plasma membrane|
|apical plasma membrane|
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\\

 === CRISPR Data ===
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^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.23|
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<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
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Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
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== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3013
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
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{{:chemogenomics:nalm6 dist.png?nolink |}}
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