======= TMEM126B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM126B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 126B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55863|55863]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IUX1|Q8IUX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM126B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM126B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1370|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|molecular function|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.91|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.73|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.7|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.7|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.77|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.81|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.87|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.92|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.96|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.2|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.26|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.27|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.37|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.44|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.55|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.56|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.68|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnaseh1|RNASEH1]]|0.526|
|[[:human genes:c:c17orf89|C17orf89]]|0.525|
|[[:human genes:s:selrc1|SELRC1]]|0.514|
|[[:human genes:y:yars2|YARS2]]|0.51|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.508|
|[[:human genes:c:c12orf65|C12orf65]]|0.502|
|[[:human genes:s:sars2|SARS2]]|0.502|
|[[:human genes:m:mrps5|MRPS5]]|0.497|
|[[:human genes:m:mrps18a|MRPS18A]]|0.493|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.491|
|[[:human genes:n:ndufa3|NDUFA3]]|0.49|
|[[:human genes:g:gatc|GATC]]|0.482|
|[[:human genes:t:tpk1|TPK1]]|0.472|
|[[:human genes:m:mrpl15|MRPL15]]|0.467|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.467|
|[[:human genes:b:bcs1l|BCS1L]]|0.464|
|[[:human genes:p:pdss1|PDSS1]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.454|
|[[:human genes:m:mrps26|MRPS26]]|0.453|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.451|
|[[:human genes:c:cox6c|COX6C]]|0.45|
|[[:human genes:t:tars2|TARS2]]|0.449|
|[[:human genes:r:rbfa|RBFA]]|0.449|
|[[:human genes:t:trmt10a|TRMT10A]]|0.443|
|[[:human genes:m:mrps6|MRPS6]]|0.443|
|[[:human genes:n:ndufs7|NDUFS7]]|0.442|
|[[:human genes:m:mrps14|MRPS14]]|0.442|
|[[:human genes:s:sco2|SCO2]]|0.441|
|[[:human genes:v:vars2|VARS2]]|0.441|
|[[:human genes:n:ndufb5|NDUFB5]]|0.441|
|[[:human genes:f:foxred1|FOXRED1]]|0.44|
|[[:human genes:p:polg|POLG]]|0.44|
|[[:human genes:c:cox16|COX16]]|0.439|
|[[:human genes:m:mrp63|MRP63]]|0.437|
|[[:human genes:s:slc25a26|SLC25A26]]|0.435|
|[[:human genes:r:rpusd4|RPUSD4]]|0.433|
|[[:human genes:n:ndufb11|NDUFB11]]|0.428|
|[[:human genes:m:mrpl34|MRPL34]]|0.428|
|[[:human genes:g:gfm2|GFM2]]|0.428|
|[[:human genes:t:tefm|TEFM]]|0.428|
|[[:human genes:m:mrpl53|MRPL53]]|0.428|
|[[:human genes:m:mrps34|MRPS34]]|0.428|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:m:mtg1|MTG1]]|0.426|
|[[:human genes:m:mtpap|MTPAP]]|0.425|
|[[:human genes:m:mrps16|MRPS16]]|0.425|
|[[:human genes:c:c19orf70|C19orf70]]|0.422|
|[[:human genes:m:mrpl23|MRPL23]]|0.417|
|[[:human genes:m:mrps21|MRPS21]]|0.417|
|[[:human genes:m:mrpl21|MRPL21]]|0.417|
|[[:human genes:e:elac2|ELAC2]]|0.413|
|[[:human genes:c:chchd4|CHCHD4]]|0.409|
|[[:human genes:t:triap1|TRIAP1]]|0.403|
|[[:human genes:q:qrsl1|QRSL1]]|0.403|
|[[:human genes:a:atp5d|ATP5D]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14251
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM126B Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>