======= TMEM133 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGAP42
  * **<color #00a2e8>Official Name</color>**: Rho GTPase activating protein 42
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=143872|143872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NI28|A6NI28]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM133&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM133|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615936|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular smooth muscle contraction|
|negative regulation of vasoconstriction|
|regulation of vascular smooth muscle contraction|
|negative regulation of smooth muscle contraction|
|negative regulation of systemic arterial blood pressure|
|negative regulation of Rho protein signal transduction|
|negative regulation of muscle contraction|
|negative regulation of blood circulation|
|negative regulation of blood pressure|
|negative regulation of Ras protein signal transduction|
|positive regulation of blood vessel diameter|
|regulation of vasoconstriction|
|negative regulation of small GTPase mediated signal transduction|
|regulation of smooth muscle contraction|
|regulation of systemic arterial blood pressure|
|activation of GTPase activity|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of Rho protein signal transduction|
|regulation of muscle contraction|
|vascular process in circulatory system|
|regulation of blood pressure|
|regulation of muscle system process|
|regulation of Ras protein signal transduction|
|GTPase activator activity|
|regulation of blood circulation|
|regulation of small GTPase mediated signal transduction|
|blood circulation|
|circulatory system process|
|positive regulation of GTPase activity|
|cellular component|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|regulation of system process|
|positive regulation of hydrolase activity|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|negative regulation of response to stimulus|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.88|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.71|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.86|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17013
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM133 Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>