======= TMEM165 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM165
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 165
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55858|55858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC07|Q9HC07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM165&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM165|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation. {ECO:0000269|PubMed:22683087, ECO:0000269|PubMed:23569283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0016|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi calcium ion transport|
|regulation of lysosomal lumen pH|
|lytic vacuole organization|
|lysosome organization|
|protein N-linked glycosylation|
|regulation of intracellular pH|
|regulation of cellular pH|
|trans-Golgi network membrane|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|late endosome membrane|
|vacuole organization|
|monovalent inorganic cation homeostasis|
|early endosome membrane|
|endosome membrane|
|calcium ion transport|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|divalent metal ion transport|
|lysosomal membrane|
|divalent inorganic cation transport|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|carbohydrate derivative biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|ion transport|
|organonitrogen compound biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-4.06|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-4.01|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.98|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.7|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.71|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.86|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.93|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.96|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.02|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.03|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.16|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.25|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.26|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.3|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.31|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.42|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.57|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|3.11|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|4.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp2c1|ATP2C1]]|0.606|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|3/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM165 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>