======= TMEM259 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM259
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 259
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91304|91304]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4ZIN3|Q4ZIN3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM259&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM259|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. {ECO:0000250|UniProtKB:Q8CIV2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Membralin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ERAD pathway|
|regulation of ERAD pathway|
|positive regulation of response to endoplasmic reticulum stress|
|regulation of response to endoplasmic reticulum stress|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of proteasomal protein catabolic process|
|negative regulation of neuron death|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|regulation of neuron death|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cellular catabolic process|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|negative regulation of cell death|
|endoplasmic reticulum|
|regulation of response to stress|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.99|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.92|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.88|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.87|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.81|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.83|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM259 Expression in NALM6 Cells: 7.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>