======= TMEM261 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMAC1
  * **<color #00a2e8>Official Name</color>**: distal membrane arm assembly complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90871|90871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GE9|Q96GE9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM261&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM261|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.86|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.88|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.88|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.14|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.27|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.29|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:grsf1|GRSF1]]|0.583|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.582|
|[[:human genes:n:ndufb11|NDUFB11]]|0.574|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.548|
|[[:human genes:n:ndufc2|NDUFC2]]|0.543|
|[[:human genes:n:ndufa2|NDUFA2]]|0.542|
|[[:human genes:m:mrps21|MRPS21]]|0.525|
|[[:human genes:n:ndufa1|NDUFA1]]|0.524|
|[[:human genes:n:ndufs2|NDUFS2]]|0.512|
|[[:human genes:a:acad9|ACAD9]]|0.509|
|[[:human genes:a:atp5sl|ATP5SL]]|0.507|
|[[:human genes:c:cars2|CARS2]]|0.506|
|[[:human genes:n:ndufb6|NDUFB6]]|0.505|
|[[:human genes:n:ndufb5|NDUFB5]]|0.504|
|[[:human genes:n:ndufa3|NDUFA3]]|0.5|
|[[:human genes:n:ndufa11|NDUFA11]]|0.496|
|[[:human genes:r:rpusd3|RPUSD3]]|0.494|
|[[:human genes:e:ecsit|ECSIT]]|0.491|
|[[:human genes:n:ndufa8|NDUFA8]]|0.49|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.488|
|[[:human genes:s:selrc1|SELRC1]]|0.486|
|[[:human genes:g:gfm2|GFM2]]|0.484|
|[[:human genes:m:mtg2|MTG2]]|0.484|
|[[:human genes:n:ndufs7|NDUFS7]]|0.483|
|[[:human genes:m:mtif2|MTIF2]]|0.481|
|[[:human genes:l:lars2|LARS2]]|0.479|
|[[:human genes:m:mto1|MTO1]]|0.479|
|[[:human genes:t:tfb1m|TFB1M]]|0.475|
|[[:human genes:r:rpusd4|RPUSD4]]|0.475|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.474|
|[[:human genes:c:c17orf89|C17orf89]]|0.471|
|[[:human genes:c:c12orf65|C12orf65]]|0.469|
|[[:human genes:f:foxred1|FOXRED1]]|0.468|
|[[:human genes:g:gfm1|GFM1]]|0.467|
|[[:human genes:c:coq2|COQ2]]|0.466|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.465|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.463|
|[[:human genes:y:yars2|YARS2]]|0.462|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.461|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.461|
|[[:human genes:q:qrsl1|QRSL1]]|0.46|
|[[:human genes:n:ndufb7|NDUFB7]]|0.46|
|[[:human genes:m:malsu1|MALSU1]]|0.46|
|[[:human genes:m:mrps16|MRPS16]]|0.458|
|[[:human genes:n:ndufc1|NDUFC1]]|0.455|
|[[:human genes:n:nars2|NARS2]]|0.454|
|[[:human genes:t:tars2|TARS2]]|0.454|
|[[:human genes:p:pdss1|PDSS1]]|0.453|
|[[:human genes:n:ndufv2|NDUFV2]]|0.452|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.45|
|[[:human genes:t:tefm|TEFM]]|0.449|
|[[:human genes:s:ssbp1|SSBP1]]|0.448|
|[[:human genes:c:chchd1|CHCHD1]]|0.447|
|[[:human genes:p:pars2|PARS2]]|0.447|
|[[:human genes:p:polg|POLG]]|0.447|
|[[:human genes:m:mrpl15|MRPL15]]|0.446|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.445|
|[[:human genes:f:ftsj2|FTSJ2]]|0.444|
|[[:human genes:t:tomm20|TOMM20]]|0.443|
|[[:human genes:n:ndufa10|NDUFA10]]|0.443|
|[[:human genes:m:mrpl21|MRPL21]]|0.442|
|[[:human genes:n:ndufb10|NDUFB10]]|0.441|
|[[:human genes:m:mrps14|MRPS14]]|0.441|
|[[:human genes:m:mcat|MCAT]]|0.44|
|[[:human genes:p:polg2|POLG2]]|0.438|
|[[:human genes:c:coa6|COA6]]|0.437|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.436|
|[[:human genes:n:ndufs5|NDUFS5]]|0.434|
|[[:human genes:m:minos1|MINOS1]]|0.432|
|[[:human genes:p:pet112|PET112]]|0.432|
|[[:human genes:n:nubpl|NUBPL]]|0.431|
|[[:human genes:n:ndufa5|NDUFA5]]|0.431|
|[[:human genes:m:mrps33|MRPS33]]|0.43|
|[[:human genes:s:sars2|SARS2]]|0.429|
|[[:human genes:m:mrps34|MRPS34]]|0.428|
|[[:human genes:n:ndufa6|NDUFA6]]|0.424|
|[[:human genes:n:ndufb9|NDUFB9]]|0.423|
|[[:human genes:n:ndufs8|NDUFS8]]|0.423|
|[[:human genes:m:mrpl45|MRPL45]]|0.421|
|[[:human genes:p:pet117|PET117]]|0.418|
|[[:human genes:m:mrps25|MRPS25]]|0.418|
|[[:human genes:n:ndufa13|NDUFA13]]|0.418|
|[[:human genes:m:mrpl53|MRPL53]]|0.418|
|[[:human genes:m:mrp63|MRP63]]|0.417|
|[[:human genes:f:fastkd2|FASTKD2]]|0.416|
|[[:human genes:t:timm21|TIMM21]]|0.416|
|[[:human genes:m:mrps6|MRPS6]]|0.414|
|[[:human genes:m:mrps12|MRPS12]]|0.413|
|[[:human genes:c:c10orf2|C10orf2]]|0.412|
|[[:human genes:t:tomm22|TOMM22]]|0.411|
|[[:human genes:m:mrpl17|MRPL17]]|0.411|
|[[:human genes:d:dap3|DAP3]]|0.41|
|[[:human genes:m:mrps5|MRPS5]]|0.41|
|[[:human genes:m:mrps28|MRPS28]]|0.409|
|[[:human genes:p:polrmt|POLRMT]]|0.409|
|[[:human genes:n:nsun4|NSUN4]]|0.409|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.407|
|[[:human genes:h:hars2|HARS2]]|0.406|
|[[:human genes:c:coa3|COA3]]|0.406|
|[[:human genes:m:mars2|MARS2]]|0.406|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.405|
|[[:human genes:r:rbfa|RBFA]]|0.404|
|[[:human genes:m:mrpl47|MRPL47]]|0.404|
|[[:human genes:m:mrps26|MRPS26]]|0.404|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.402|
|[[:human genes:m:mtif3|MTIF3]]|0.402|
|[[:human genes:m:mrpl20|MRPL20]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1531
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM261 Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>