======= TMEM33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM33
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55161|55161]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57088|P57088]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0121|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of PERK-mediated unfolded protein response|
|regulation of endoplasmic reticulum tubular network organization|
|positive regulation of IRE1-mediated unfolded protein response|
|regulation of PERK-mediated unfolded protein response|
|regulation of IRE1-mediated unfolded protein response|
|positive regulation of endoplasmic reticulum unfolded protein response|
|regulation of endoplasmic reticulum unfolded protein response|
|positive regulation of response to endoplasmic reticulum stress|
|nuclear pore|
|regulation of response to endoplasmic reticulum stress|
|melanosome|
|integral component of endoplasmic reticulum membrane|
|nuclear envelope|
|response to endoplasmic reticulum stress|
|regulation of cellular response to stress|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|regulation of organelle organization|
|regulation of response to stress|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM33 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>