======= TMOD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMOD1
  * **<color #00a2e8>Official Name</color>**: tropomodulin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7111|7111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28289|P28289]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMOD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMOD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:8002995}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tropomodulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pointed-end actin filament capping|
|lens fiber cell development|
|tropomyosin binding|
|striated muscle thin filament|
|cortical cytoskeleton|
|lens fiber cell differentiation|
|myofibril|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|COP9 signalosome|
|muscle filament sliding|
|actin-myosin filament sliding|
|sarcomere|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|myofibril assembly|
|negative regulation of protein complex disassembly|
|lens development in camera-type eye|
|adult locomotory behavior|
|actin filament|
|regulation of protein depolymerization|
|actin-mediated cell contraction|
|cellular component assembly involved in morphogenesis|
|actin filament-based movement|
|regulation of protein complex disassembly|
|actomyosin structure organization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|striated muscle cell development|
|negative regulation of cytoskeleton organization|
|adult behavior|
|muscle cell development|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|epithelial cell development|
|locomotory behavior|
|striated muscle cell differentiation|
|actin filament binding|
|regulation of protein polymerization|
|muscle cell differentiation|
|muscle contraction|
|regulation of actin filament organization|
|actin binding|
|muscle system process|
|camera-type eye development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|sensory system development|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|sensory organ development|
|actin filament-based process|
|behavior|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|cytoskeleton organization|
|epithelium development|
|regulation of organelle organization|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMOD1 Expression in NALM6 Cells: 2.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>