======= TMOD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMOD4
  * **<color #00a2e8>Official Name</color>**: tropomodulin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29765|29765]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZQ9|Q9NZQ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMOD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMOD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tropomodulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pointed-end actin filament capping|
|tropomyosin binding|
|striated muscle thin filament|
|myofibril|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|myofibril assembly|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|cellular component assembly involved in morphogenesis|
|regulation of protein complex disassembly|
|actomyosin structure organization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|striated muscle cell development|
|negative regulation of cytoskeleton organization|
|muscle cell development|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|striated muscle cell differentiation|
|actin filament binding|
|regulation of protein polymerization|
|muscle cell differentiation|
|muscle contraction|
|regulation of actin filament organization|
|muscle system process|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|actin filament-based process|
|negative regulation of cellular component organization|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|cytoskeleton organization|
|regulation of organelle organization|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.72|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.93|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13854
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMOD4 Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>