======= TMSB15B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMSB15B
  * **<color #00a2e8>Official Name</color>**: thymosin beta 15B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=286527|286527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CG35|P0CG35]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMSB15B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMSB15B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration. {ECO:0000250, ECO:0000269|PubMed:19296525}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thymosin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of actin monomers|
|actin monomer binding|
|negative regulation of actin filament polymerization|
|negative regulation of protein polymerization|
|maintenance of protein location in cell|
|maintenance of location in cell|
|maintenance of protein location|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|maintenance of location|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of protein polymerization|
|actin filament organization|
|regulation of actin filament organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|cellular component|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|actin filament-based process|
|negative regulation of cellular component organization|
|molecular function|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|cytoskeleton organization|
|regulation of organelle organization|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.23|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.22|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.12|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.81|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.72|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.72|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.73|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.76|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.76|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.89|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.93|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.95|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.01|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.01|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.02|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.03|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.09|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.11|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.12|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.14|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.17|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.19|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.2|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.24|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.41|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.49|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.59|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.77|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|3.02|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|3.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18394
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMSB15B Expression in NALM6 Cells: 3.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>