======= TNC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNC
  * **<color #00a2e8>Official Name</color>**: tenascin C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3371|3371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24821|P24821]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF 2|
|fn3|
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mesenchymal-epithelial cell signaling involved in prostate gland development|
|perisynaptic extracellular matrix|
|bud outgrowth involved in lung branching|
|cellular response to prostaglandin D stimulus|
|response to prostaglandin D|
|peripheral nervous system axon regeneration|
|syndecan binding|
|mesenchymal-epithelial cell signaling|
|interstitial matrix|
|cellular response to vitamin D|
|branch elongation of an epithelium|
|prostate gland epithelium morphogenesis|
|cellular response to prostaglandin stimulus|
|axon regeneration|
|cellular response to vitamin|
|prostate gland morphogenesis|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|neuron projection regeneration|
|response to vitamin D|
|response to prostaglandin|
|prostate gland development|
|neuromuscular junction development|
|lung morphogenesis|
|response to axon injury|
|cellular response to fatty acid|
|cellular response to nutrient|
|cellular response to retinoic acid|
|odontogenesis of dentin-containing tooth|
|cellular response to alcohol|
|response to fatty acid|
|response to vitamin|
|basement membrane|
|cellular response to ketone|
|gland morphogenesis|
|response to retinoic acid|
|developmental growth involved in morphogenesis|
|response to fibroblast growth factor|
|odontogenesis|
|response to ethanol|
|osteoblast differentiation|
|branching morphogenesis of an epithelial tube|
|extracellular matrix structural constituent|
|regeneration|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|response to ketone|
|respiratory system development|
|cellular response to acid chemical|
|response to mechanical stimulus|
|response to nutrient|
|response to alcohol|
|cellular response to nutrient levels|
|ossification|
|cellular response to extracellular stimulus|
|synapse organization|
|negative regulation of cell adhesion|
|response to antibiotic|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|urogenital system development|
|cellular response to external stimulus|
|extracellular matrix organization|
|response to acid chemical|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|developmental growth|
|growth|
|axon development|
|gland development|
|focal adhesion|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|wound healing|
|response to nutrient levels|
|response to toxic substance|
|cellular response to lipid|
|response to extracellular stimulus|
|response to growth factor|
|cellular response to organic cyclic compound|
|tissue morphogenesis|
|response to wounding|
|cellular response to hormone stimulus|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|neuron development|
|tube development|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|cellular response to stress|
|tissue development|
|extracellular region|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.82|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.8|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.84|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.87|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNC Expression in NALM6 Cells: 1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>