======= TNF =======
== Gene Information ==
* **Official Symbol**: TNF
* **Official Name**: tumor necrosis factor
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7124|7124]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P01375|P01375]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=TNF&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNF|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/191160|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.
|TNF|
|positive regulation of leukocyte adhesion to arterial endothelial cell|
|negative regulation of branching involved in lung morphogenesis|
|positive regulation of translational initiation by iron|
|positive regulation of fractalkine biosynthetic process|
|chronic inflammatory response to antigenic stimulus|
|positive regulation of fractalkine production|
|regulation of fractalkine production|
|positive regulation of chronic inflammatory response to antigenic stimulus|
|regulation of blood microparticle formation|
|positive regulation of blood microparticle formation|
|regulation of leukocyte adhesion to arterial endothelial cell|
|regulation of fractalkine biosynthetic process|
|positive regulation of vitamin D biosynthetic process|
|positive regulation of superoxide dismutase activity|
|positive regulation of calcidiol 1-monooxygenase activity|
|positive regulation of removal of superoxide radicals|
|regulation of chronic inflammatory response to antigenic stimulus|
|negative regulation of alkaline phosphatase activity|
|regulation of translational initiation by iron|
|sequestering of triglyceride|
|negative regulation of bicellular tight junction assembly|
|positive regulation of chronic inflammatory response|
|positive regulation of vitamin metabolic process|
|regulation of superoxide dismutase activity|
|epithelial cell proliferation involved in salivary gland morphogenesis|
|positive regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of myosin-light-chain-phosphatase activity|
|receptor biosynthetic process|
|regulation of branching involved in lung morphogenesis|
|negative regulation of cytokine secretion involved in immune response|
|necroptotic signaling pathway|
|regulation of calcidiol 1-monooxygenase activity|
|positive regulation of fever generation|
|regulation of myosin-light-chain-phosphatase activity|
|endothelial cell apoptotic process|
|regulation of fever generation|
|positive regulation of response to reactive oxygen species|
|death-inducing signaling complex assembly|
|negative regulation of amyloid-beta clearance|
|regulation of vitamin D biosynthetic process|
|regulation of chronic inflammatory response|
|regulation of branching involved in salivary gland morphogenesis|
|cellular response to nicotine|
|regulation of alkaline phosphatase activity|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of removal of superoxide radicals|
|positive regulation of sphingolipid biosynthetic process|
|positive regulation of ceramide biosynthetic process|
|positive regulation of heat generation|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|positive regulation of hormone biosynthetic process|
|chronic inflammatory response|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|activation of MAPKKK activity|
|positive regulation of podosome assembly|
|positive regulation of chemokine biosynthetic process|
|positive regulation of interleukin-8 biosynthetic process|
|positive regulation of hair follicle development|
|positive regulation of inflammatory response to antigenic stimulus|
|negative regulation of glucose import|
|positive regulation of hair cycle|
|regulation of heat generation|
|regulation of vitamin metabolic process|
|regulation of endothelial cell development|
|positive regulation of neuroinflammatory response|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|regulation of establishment of endothelial barrier|
|regulation of chemokine biosynthetic process|
|positive regulation of membrane protein ectodomain proteolysis|
|positive regulation of chemokine secretion|
|positive regulation of interleukin-6 biosynthetic process|
|positive regulation of amyloid-beta formation|
|positive regulation of glial cell proliferation|
|positive regulation of hormone metabolic process|
|regulation of ceramide biosynthetic process|
|negative regulation of morphogenesis of an epithelium|
|regulation of chemokine secretion|
|regulation of interleukin-8 biosynthetic process|
|positive regulation of calcineurin-mediated signaling|
|regulation of cytokine secretion involved in immune response|
|regulation of amyloid-beta clearance|
|regulation of podosome assembly|
|regulation of membrane lipid metabolic process|
|regulation of sphingolipid biosynthetic process|
|positive regulation of heterotypic cell-cell adhesion|
|positive regulation of calcineurin-NFAT signaling cascade|
|positive regulation of protein localization to cell surface|
|positive regulation of humoral immune response|
|negative regulation of glucose transmembrane transport|
|positive regulation of cellular response to oxidative stress|
|positive regulation of steroid biosynthetic process|
|leukocyte tethering or rolling|
|negative regulation of lipid storage|
|positive regulation of amyloid precursor protein catabolic process|
|regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of response to oxidative stress|
|leukocyte adhesion to vascular endothelial cell|
|regulation of immunoglobulin secretion|
|astrocyte activation|
|regulation of hair follicle development|
|positive regulation of nitric-oxide synthase activity|
|regulation of bicellular tight junction assembly|
|response to salt stress|
|regulation of membrane protein ectodomain proteolysis|
|regulation of interleukin-6 biosynthetic process|
|negative regulation of cell junction assembly|
|negative regulation of lipid catabolic process|
|necroptotic process|
|inflammatory response to antigenic stimulus|
|regulation of inflammatory response to antigenic stimulus|
|positive regulation of mononuclear cell migration|
|negative regulation of myoblast differentiation|
|positive regulation of alcohol biosynthetic process|
|negative regulation of cytokine production involved in immune response|
|regulation of heterotypic cell-cell adhesion|
|positive regulation of osteoclast differentiation|
|positive regulation of monooxygenase activity|
|phagocytic cup|
|regulation of amyloid-beta formation|
|positive regulation of steroid metabolic process|
|regulation of hormone biosynthetic process|
|epithelial cell apoptotic process|
|programmed necrotic cell death|
|regulation of hair cycle|
|positive regulation of acute inflammatory response|
|salivary gland morphogenesis|
|lipid storage|
|microglial cell activation|
|regulation of glial cell proliferation|
|positive regulation of translational initiation|
|necrotic cell death|
|leukocyte activation involved in inflammatory response|
|positive regulation of interleukin-6 secretion|
|regulation of neuroinflammatory response|
|tumor necrosis factor receptor binding|
|salivary gland development|
|regulation of superoxide metabolic process|
|positive regulation of vascular smooth muscle cell proliferation|
|regulation of endothelial cell differentiation|
|regulation of amyloid precursor protein catabolic process|
|negative regulation of animal organ morphogenesis|
|regulation of calcineurin-NFAT signaling cascade|
|extrinsic apoptotic signaling pathway via death domain receptors|
|lipopolysaccharide-mediated signaling pathway|
|embryonic digestive tract development|
|regulation of calcineurin-mediated signaling|
|regulation of response to reactive oxygen species|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of signal transduction in absence of ligand|
|astrocyte development|
|positive regulation of B cell mediated immunity|
|negative regulation of endothelial cell proliferation|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of protein complex disassembly|
|glial cell activation|
|regulation of protein localization to cell surface|
|regulation of hormone metabolic process|
|protein kinase B signaling|
|positive regulation of nitric oxide biosynthetic process|
|cellular extravasation|
|positive regulation of epidermis development|
|positive regulation of nitric oxide metabolic process|
|negative regulation of lipid localization|
|neuroinflammatory response|
|cortical actin cytoskeleton organization|
|negative regulation of interleukin-6 production|
|exocrine system development|
|negative regulation of osteoblast differentiation|
|positive regulation of calcium-mediated signaling|
|regulation of nitric-oxide synthase activity|
|osteoclast differentiation|
|regulation of acute inflammatory response|
|regulation of lipid storage|
|negative regulation of fat cell differentiation|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of mononuclear cell migration|
|cortical cytoskeleton organization|
|positive regulation of interleukin-8 production|
|response to nicotine|
|positive regulation of reactive oxygen species biosynthetic process|
|macrophage activation|
|regulation of vascular smooth muscle cell proliferation|
|regulation of endothelial cell apoptotic process|
|leukocyte cell-cell adhesion|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|positive regulation of oxidoreductase activity|
|regulation of myoblast differentiation|
|astrocyte differentiation|
|positive regulation of neuron apoptotic process|
|regulation of lipid catabolic process|
|regulation of monooxygenase activity|
|positive regulation of myeloid leukocyte differentiation|
|regulation of glucose import|
|positive regulation of protein localization to plasma membrane|
|positive regulation of chemokine production|
|regulation of nitric oxide biosynthetic process|
|regulation of morphogenesis of a branching structure|
|negative regulation of viral genome replication|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of phosphoprotein phosphatase activity|
|positive regulation of protein localization to cell periphery|
|regulation of immunoglobulin production|
|positive regulation of interferon-gamma production|
|regulation of osteoclast differentiation|
|negative regulation of protein dephosphorylation|
|positive regulation of cytokine biosynthetic process|
|negative regulation of cytokine secretion|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of phagocytosis|
|regulation of interleukin-8 production|
|cellular response to amino acid stimulus|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of gliogenesis|
|negative regulation of protein complex disassembly|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of JUN kinase activity|
|negative regulation of ossification|
|regulation of glucose transmembrane transport|
|regulation of cellular response to oxidative stress|
|regulation of alcohol biosynthetic process|
|positive regulation of organelle assembly|
|response to osmotic stress|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of chemokine production|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of epithelial cell apoptotic process|
|regulation of translational initiation|
|positive regulation of lipid biosynthetic process|
|JNK cascade|
|negative regulation of viral life cycle|
|negative regulation of lipid metabolic process|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of cytokine production involved in immune response|
|regulation of response to oxidative stress|
|positive regulation of smooth muscle cell proliferation|
|regulation of reactive oxygen species biosynthetic process|
|regulation of epidermis development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|epithelial cell proliferation|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of JUN kinase activity|
|regulation of steroid biosynthetic process|
|positive regulation of receptor signaling pathway via STAT|
|regulation of cell junction assembly|
|positive regulation of myeloid cell differentiation|
|positive regulation of neuron death|
|regulation of viral genome replication|
|defense response to Gram-positive bacterium|
|positive regulation of interleukin-6 production|
|regulation of protein localization to plasma membrane|
|regulation of oxidoreductase activity|
|regulation of phagocytosis|
|positive regulation of reactive oxygen species metabolic process|
|regulation of calcium-mediated signaling|
|extrinsic apoptotic signaling pathway|
|negative regulation of viral process|
|gland morphogenesis|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of extrinsic apoptotic signaling pathway|
|protease binding|
|negative regulation of phosphatase activity|
|regulation of cytokine biosynthetic process|
|positive regulation of peptidyl-serine phosphorylation|
|receptor metabolic process|
|stress-activated MAPK cascade|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|glial cell development|
|regulation of NIK/NF-kappaB signaling|
|myeloid leukocyte differentiation|
|negative regulation of dephosphorylation|
|regulation of osteoblast differentiation|
|glucose metabolic process|
|regulation of protein complex disassembly|
|regulation of steroid metabolic process|
|regulation of protein localization to cell periphery|
|response to amino acid|
|regulation of gliogenesis|
|regulation of myeloid leukocyte differentiation|
|negative regulation of transmembrane transport|
|recycling endosome|
|regulation of phosphoprotein phosphatase activity|
|tumor necrosis factor-mediated signaling pathway|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of immune effector process|
|regulation of fat cell differentiation|
|positive regulation of protein localization to membrane|
|negative regulation of epithelial cell proliferation|
|positive regulation of translation|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|digestive tract development|
|negative regulation of protein secretion|
|regulation of smooth muscle cell proliferation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|regulation of humoral immune response|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of inflammatory response|
|negative regulation of peptide secretion|
|positive regulation of JNK cascade|
|positive regulation of cytokine secretion|
|regulation of protein dephosphorylation|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|positive regulation of lipid metabolic process|
|regulation of epithelial cell differentiation|
|stress-activated protein kinase signaling cascade|
|digestive system development|
|response to glucocorticoid|
|regulation of viral life cycle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|intrinsic apoptotic signaling pathway|
|regulation of lymphocyte mediated immunity|
|positive regulation of synaptic transmission|
|positive regulation of cellular amide metabolic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|hexose metabolic process|
|regulation of adaptive immune response|
|response to corticosteroid|
|maintenance of location|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|glial cell differentiation|
|positive regulation of endopeptidase activity|
|cytokine activity|
|regulation of response to cytokine stimulus|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|regulation of reactive oxygen species metabolic process|
|regulation of morphogenesis of an epithelium|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|regulation of lipid biosynthetic process|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of ossification|
|cellular response to molecule of bacterial origin|
|positive regulation of peptidase activity|
|regulation of leukocyte migration|
|monosaccharide metabolic process|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|regulation of viral process|
|regulation of neuron apoptotic process|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|cellular response to toxic substance|
|gliogenesis|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of protein catabolic process|
|transcription regulatory region DNA binding|
|regulation of synapse organization|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of organelle assembly|
|regulation of protein kinase B signaling|
|regulation of symbiosis, encompassing mutualism through parasitism|
|membrane raft|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|response to virus|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|cognition|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|regulation of neuron death|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|lipid localization|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|response to steroid hormone|
|activation of protein kinase activity|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|response to acid chemical|
|humoral immune response|
|regulation of translation|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|leukocyte migration|
|regulation of protein catabolic process|
|extracellular structure organization|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|positive regulation of cell adhesion|
|gland development|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|embryonic organ development|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|carbohydrate metabolic process|
|protein localization to membrane|
|negative regulation of transport|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|cell-cell adhesion|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|actin filament-based process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 10769
* **Expression level (log2 read counts)**: -0.54
{{:chemogenomics:nalm6 dist.png?nolink |}}