======= TNFRSF11A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF11A
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 11a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8792|8792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6Q6|Q9Y6Q6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF11A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF11A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|
|positive regulation of fever generation by positive regulation of prostaglandin secretion|
|circadian temperature homeostasis|
|TNFSF11-mediated signaling pathway|
|positive regulation of fever generation|
|regulation of fever generation|
|multinuclear osteoclast differentiation|
|tumor necrosis factor-activated receptor activity|
|positive regulation of prostaglandin secretion|
|regulation of prostaglandin secretion|
|positive regulation of heat generation|
|regulation of heat generation|
|positive regulation of icosanoid secretion|
|lymph node development|
|mammary gland lobule development|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|positive regulation of fatty acid transport|
|mammary gland alveolus development|
|regulation of icosanoid secretion|
|regulation of fatty acid transport|
|positive regulation of acute inflammatory response|
|temperature homeostasis|
|positive regulation of tissue remodeling|
|positive regulation of organic acid transport|
|regulation of bone resorption|
|cytokine binding|
|monocyte chemotaxis|
|osteoclast differentiation|
|regulation of acute inflammatory response|
|regulation of bone remodeling|
|mononuclear cell migration|
|positive regulation of anion transport|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|positive regulation of JUN kinase activity|
|regulation of tissue remodeling|
|positive regulation of lipid localization|
|regulation of JUN kinase activity|
|regulation of anion transport|
|regulation of lipid transport|
|myeloid leukocyte differentiation|
|tumor necrosis factor-mediated signaling pathway|
|myeloid leukocyte migration|
|mammary gland development|
|transmembrane signaling receptor activity|
|regulation of lipid localization|
|positive regulation of inflammatory response|
|positive regulation of JNK cascade|
|circadian rhythm|
|leukocyte chemotaxis|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|response to interleukin-1|
|signaling receptor activity|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|myeloid cell differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|ossification|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|positive regulation of ion transport|
|rhythmic process|
|regulation of ERK1 and ERK2 cascade|
|response to lipopolysaccharide|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|leukocyte migration|
|external side of plasma membrane|
|gland development|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|response to radiation|
|positive regulation of defense response|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|hemopoiesis|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of ion transport|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of protein kinase activity|
|regulation of secretion|
|response to lipid|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|cell migration|
|regulation of transferase activity|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.7|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.7|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF11A Expression in NALM6 Cells: 0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>