======= TNFRSF12A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF12A
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 12A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51330|51330]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP84|Q9NP84]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF12A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF12A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|stn TNFRSF12A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|substrate-dependent cell migration, cell attachment to substrate|
|substrate-dependent cell migration|
|positive regulation of axon extension|
|positive regulation of extrinsic apoptotic signaling pathway|
|positive regulation of axonogenesis|
|ruffle|
|regulation of axon extension|
|extrinsic apoptotic signaling pathway|
|regulation of extent of cell growth|
|tumor necrosis factor-mediated signaling pathway|
|regulation of wound healing|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|regulation of response to wounding|
|positive regulation of developmental growth|
|positive regulation of apoptotic signaling pathway|
|regulation of cell size|
|regulation of axonogenesis|
|cell-substrate adhesion|
|cellular response to tumor necrosis factor|
|positive regulation of growth|
|response to tumor necrosis factor|
|positive regulation of neuron projection development|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|regulation of cell morphogenesis involved in differentiation|
|angiogenesis|
|regulation of vasculature development|
|regulation of developmental growth|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|regulation of cell growth|
|positive regulation of neurogenesis|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cell death|
|response to cytokine|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13826
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF12A Expression in NALM6 Cells: -0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>