======= TNFRSF1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF1B
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7133|7133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20333|P20333]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191191|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial cell-neuron signaling|
|tumor necrosis factor binding|
|tumor necrosis factor receptor superfamily complex|
|negative regulation of extracellular matrix constituent secretion|
|positive regulation of apoptotic process involved in development|
|positive regulation of apoptotic process involved in morphogenesis|
|regulation of extracellular matrix constituent secretion|
|varicosity|
|tumor necrosis factor-activated receptor activity|
|negative regulation of extracellular matrix organization|
|negative regulation of neuroinflammatory response|
|regulation of apoptotic process involved in development|
|regulation of apoptotic process involved in morphogenesis|
|positive regulation of membrane protein ectodomain proteolysis|
|regulation of cytokine secretion involved in immune response|
|positive regulation of myelination|
|pulmonary valve development|
|positive regulation of oligodendrocyte differentiation|
|regulation of membrane protein ectodomain proteolysis|
|negative regulation of cardiac muscle hypertrophy|
|negative regulation of muscle hypertrophy|
|regulation of neuroinflammatory response|
|regulation of T cell cytokine production|
|aortic valve development|
|RNA destabilization|
|semi-lunar valve development|
|regulation of extracellular matrix organization|
|regulation of oligodendrocyte differentiation|
|positive regulation of glial cell differentiation|
|regulation of myelination|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|heart valve development|
|positive regulation of nervous system process|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|regulation of T cell mediated immunity|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of cytokine production involved in immune response|
|regulation of muscle adaptation|
|specific granule membrane|
|extrinsic apoptotic signaling pathway|
|regulation of gliogenesis|
|tumor necrosis factor-mediated signaling pathway|
|regulation of nervous system process|
|negative regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|intrinsic apoptotic signaling pathway|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|regulation of RNA stability|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of protein catabolic process|
|regulation of leukocyte proliferation|
|membrane raft|
|negative regulation of secretion|
|regulation of muscle system process|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|aging|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|neuronal cell body|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|inflammatory response|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|myeloid leukocyte activation|
|regulation of system process|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|response to lipid|
|circulatory system development|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of catabolic process|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7534
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF1B Expression in NALM6 Cells: 3.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>