======= TNFSF18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF18
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8995|8995]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNG2|Q9UNG2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T cell proliferation involved in immune response|
|tumor necrosis factor receptor superfamily binding|
|T cell proliferation|
|T cell activation involved in immune response|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of tyrosine phosphorylation of STAT protein|
|lymphocyte proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|mononuclear cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|leukocyte proliferation|
|lymphocyte activation involved in immune response|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of leukocyte migration|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|cytokine activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|T cell activation|
|cellular response to tumor necrosis factor|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|regulation of T cell activation|
|signaling receptor binding|
|lymphocyte activation|
|positive regulation of cell adhesion|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|immune effector process|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17324
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF18 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>