======= TOB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOB1
  * **<color #00a2e8>Official Name</color>**: transducer of ERBB2, 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10140|10140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50616|P50616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|CCR4-NOT complex|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of SMAD protein signal transduction|
|negative regulation of osteoblast differentiation|
|positive regulation of mRNA catabolic process|
|negative regulation of BMP signaling pathway|
|SMAD binding|
|negative regulation of mRNA catabolic process|
|SH3/SH2 adaptor activity|
|receptor tyrosine kinase binding|
|negative regulation of RNA catabolic process|
|negative regulation of ossification|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|regulation of BMP signaling pathway|
|regulation of osteoblast differentiation|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of translation|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of cellular amide metabolic process|
|regulation of ossification|
|regulation of mRNA catabolic process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription corepressor activity|
|negative regulation of cellular catabolic process|
|regulation of cellular response to growth factor stimulus|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|posttranscriptional regulation of gene expression|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|regulation of cellular catabolic process|
|negative regulation of developmental process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.91|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.86|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.84|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOB1 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>