======= TOMM22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOMM22
  * **<color #00a2e8>Official Name</color>**: translocase of outer mitochondrial membrane 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56993|56993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS69|Q9NS69]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOMM22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOMM22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. {ECO:0000269|PubMed:10982837}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tom22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial outer membrane|
|outer mitochondrial membrane organization|
|mitochondrial outer membrane translocase complex|
|establishment of protein localization to mitochondrial membrane|
|protein transmembrane transporter activity|
|protein insertion into mitochondrial membrane|
|protein insertion into membrane|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial membrane organization|
|protein import|
|macroautophagy|
|mitochondrial outer membrane|
|mitochondrial transport|
|process utilizing autophagic mechanism|
|autophagy|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|protein localization to organelle|
|membrane organization|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.75|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.81|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.83|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps16|MRPS16]]|0.534|
|[[:human genes:m:mrpl21|MRPL21]]|0.522|
|[[:human genes:m:mrps21|MRPS21]]|0.516|
|[[:human genes:g:gfm1|GFM1]]|0.502|
|[[:human genes:y:yars2|YARS2]]|0.5|
|[[:human genes:r:rpusd4|RPUSD4]]|0.499|
|[[:human genes:m:mrps6|MRPS6]]|0.494|
|[[:human genes:t:triap1|TRIAP1]]|0.494|
|[[:human genes:p:pnpt1|PNPT1]]|0.487|
|[[:human genes:s:sars2|SARS2]]|0.476|
|[[:human genes:c:cox17|COX17]]|0.475|
|[[:human genes:m:mrpl47|MRPL47]]|0.474|
|[[:human genes:t:tufm|TUFM]]|0.466|
|[[:human genes:d:dap3|DAP3]]|0.464|
|[[:human genes:t:tefm|TEFM]]|0.464|
|[[:human genes:e:elac2|ELAC2]]|0.462|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.461|
|[[:human genes:m:mrps33|MRPS33]]|0.46|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.46|
|[[:human genes:p:pdss1|PDSS1]]|0.452|
|[[:human genes:c:cox16|COX16]]|0.45|
|[[:human genes:f:fastkd5|FASTKD5]]|0.446|
|[[:human genes:m:mrps11|MRPS11]]|0.443|
|[[:human genes:s:slc25a26|SLC25A26]]|0.443|
|[[:human genes:d:dars2|DARS2]]|0.441|
|[[:human genes:m:mrps25|MRPS25]]|0.441|
|[[:human genes:a:atxn10|ATXN10]]|0.441|
|[[:human genes:f:fh|FH]]|0.44|
|[[:human genes:m:mrps14|MRPS14]]|0.439|
|[[:human genes:m:mrp63|MRP63]]|0.437|
|[[:human genes:m:mrps34|MRPS34]]|0.435|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.434|
|[[:human genes:n:nars2|NARS2]]|0.433|
|[[:human genes:m:mrps26|MRPS26]]|0.432|
|[[:human genes:m:mrpl23|MRPL23]]|0.432|
|[[:human genes:c:c17orf89|C17orf89]]|0.431|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.429|
|[[:human genes:w:wbscr16|WBSCR16]]|0.429|
|[[:human genes:z:zrsr2|ZRSR2]]|0.428|
|[[:human genes:r:rars2|RARS2]]|0.428|
|[[:human genes:s:selrc1|SELRC1]]|0.426|
|[[:human genes:h:hars2|HARS2]]|0.425|
|[[:human genes:q:qrsl1|QRSL1]]|0.425|
|[[:human genes:r:rpusd3|RPUSD3]]|0.423|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.419|
|[[:human genes:m:mrps18a|MRPS18A]]|0.419|
|[[:human genes:m:mrps5|MRPS5]]|0.418|
|[[:human genes:c:c12orf65|C12orf65]]|0.418|
|[[:human genes:f:ftsj2|FTSJ2]]|0.416|
|[[:human genes:n:ndufa1|NDUFA1]]|0.414|
|[[:human genes:m:mrpl53|MRPL53]]|0.413|
|[[:human genes:m:mrpl15|MRPL15]]|0.411|
|[[:human genes:c:coa5|COA5]]|0.411|
|[[:human genes:t:tmem261|TMEM261]]|0.411|
|[[:human genes:m:mars2|MARS2]]|0.41|
|[[:human genes:t:tomm40|TOMM40]]|0.41|
|[[:human genes:m:mrpl20|MRPL20]]|0.41|
|[[:human genes:l:lars2|LARS2]]|0.409|
|[[:human genes:m:mrps23|MRPS23]]|0.409|
|[[:human genes:m:mrpl27|MRPL27]]|0.408|
|[[:human genes:m:mrpl4|MRPL4]]|0.407|
|[[:human genes:n:ndufb3|NDUFB3]]|0.406|
|[[:human genes:t:tomm20|TOMM20]]|0.404|
|[[:human genes:c:coq5|COQ5]]|0.402|
|[[:human genes:v:vars2|VARS2]]|0.401|
|[[:human genes:g:gatc|GATC]]|0.401|
|[[:human genes:t:thg1l|THG1L]]|0.4|
|[[:human genes:c:coq2|COQ2]]|0.4|
|[[:human genes:n:ndufa3|NDUFA3]]|0.4|
|[[:human genes:r:rbfa|RBFA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 731/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 183
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOMM22 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>