======= TOP1MT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOP1MT
  * **<color #00a2e8>Official Name</color>**: DNA topoisomerase I mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116447|116447]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969P6|Q969P6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOP1MT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOP1MT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606387|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269|PubMed:11526219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Topoisom I N|
|Topoisom I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase type I activity|
|DNA topological change|
|mitochondrial nucleoid|
|chromosome|
|DNA replication|
|DNA conformation change|
|DNA metabolic process|
|chromosome organization|
|mitochondrion|
|DNA binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.87|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.95|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.85|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.73|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.71|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.72|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.76|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.77|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.81|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.87|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.88|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.01|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.05|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.1|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.11|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.11|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.11|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.12|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.13|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.15|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.19|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.2|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.42|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.68|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.615|
|[[:human genes:d:ddtl|DDTL]]|0.512|
|[[:human genes:p:psmd11|PSMD11]]|0.497|
|[[:human genes:p:psmb4|PSMB4]]|0.483|
|[[:human genes:p:psma6|PSMA6]]|0.478|
|[[:human genes:p:psmb1|PSMB1]]|0.471|
|[[:human genes:r:rps28|RPS28]]|0.47|
|[[:human genes:p:psmd1|PSMD1]]|0.469|
|[[:human genes:z:znf106|ZNF106]]|0.468|
|[[:human genes:e:elmod3|ELMOD3]]|0.466|
|[[:human genes:r:rps12|RPS12]]|0.466|
|[[:human genes:n:nup43|NUP43]]|0.466|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.465|
|[[:human genes:s:scaf1|SCAF1]]|0.465|
|[[:human genes:s:supt6h|SUPT6H]]|0.461|
|[[:human genes:o:orc1|ORC1]]|0.461|
|[[:human genes:h:hap1|HAP1]]|0.459|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.459|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.456|
|[[:human genes:m:myb|MYB]]|0.451|
|[[:human genes:d:ddt|DDT]]|0.449|
|[[:human genes:n:npipb4|NPIPB4]]|0.442|
|[[:human genes:r:rpl14|RPL14]]|0.44|
|[[:human genes:p:psmd13|PSMD13]]|0.44|
|[[:human genes:t:tfip11|TFIP11]]|0.44|
|[[:human genes:k:kctd17|KCTD17]]|0.439|
|[[:human genes:c:cbwd5|CBWD5]]|0.438|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.438|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.437|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.437|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.437|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.437|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.436|
|[[:human genes:r:rfc1|RFC1]]|0.436|
|[[:human genes:c:cbwd3|CBWD3]]|0.435|
|[[:human genes:t:tceb3c|TCEB3C]]|0.433|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.432|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.429|
|[[:human genes:p:pcf11|PCF11]]|0.429|
|[[:human genes:t:twistnb|TWISTNB]]|0.429|
|[[:human genes:z:znf830|ZNF830]]|0.427|
|[[:human genes:t:terf2|TERF2]]|0.425|
|[[:human genes:t:traip|TRAIP]]|0.424|
|[[:human genes:d:dtl|DTL]]|0.423|
|[[:human genes:r:rpl34|RPL34]]|0.423|
|[[:human genes:c:cdc6|CDC6]]|0.421|
|[[:human genes:v:vasn|VASN]]|0.421|
|[[:human genes:m:med17|MED17]]|0.42|
|[[:human genes:r:rpl30|RPL30]]|0.42|
|[[:human genes:a:akirin2|AKIRIN2]]|0.419|
|[[:human genes:i:iscu|ISCU]]|0.419|
|[[:human genes:r:rps14|RPS14]]|0.418|
|[[:human genes:p:psmc6|PSMC6]]|0.417|
|[[:human genes:c:ccdc94|CCDC94]]|0.417|
|[[:human genes:n:nop16|NOP16]]|0.416|
|[[:human genes:r:rps27a|RPS27A]]|0.415|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:i:ints6|INTS6]]|0.413|
|[[:human genes:r:rps2|RPS2]]|0.413|
|[[:human genes:f:fbxo5|FBXO5]]|0.41|
|[[:human genes:t:ttc31|TTC31]]|0.41|
|[[:human genes:c:cdc45|CDC45]]|0.409|
|[[:human genes:a:ankle2|ANKLE2]]|0.408|
|[[:human genes:t:ticrr|TICRR]]|0.407|
|[[:human genes:p:psmd7|PSMD7]]|0.406|
|[[:human genes:p:paf1|PAF1]]|0.406|
|[[:human genes:s:sf3a1|SF3A1]]|0.405|
|[[:human genes:p:psmc1|PSMC1]]|0.405|
|[[:human genes:r:riok2|RIOK2]]|0.404|
|[[:human genes:w:wdr43|WDR43]]|0.404|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:n:nbpf10|NBPF10]]|0.404|
|[[:human genes:w:wdr87|WDR87]]|0.404|
|[[:human genes:o:ogfr|OGFR]]|0.403|
|[[:human genes:c:chmp4b|CHMP4B]]|0.403|
|[[:human genes:s:syt9|SYT9]]|0.403|
|[[:human genes:o:or10g3|OR10G3]]|0.403|
|[[:human genes:r:rbbp5|RBBP5]]|0.402|
|[[:human genes:s:snrnp70|SNRNP70]]|0.401|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.4|
|[[:human genes:t:terf1|TERF1]]|0.4|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 906
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOP1MT Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>