======= TOX4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOX4
  * **<color #00a2e8>Official Name</color>**: TOX high mobility group box family member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9878|9878]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94842|O94842]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOX4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOX4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:20516061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PTW/PP1 phosphatase complex|
|nuclear chromosome, telomeric region|
|chromatin|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.92|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.84|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.77|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.84|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.98|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.15|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.28|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.64|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rhoh|RHOH]]|0.409|
|[[:human genes:p:pik3cd|PIK3CD]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOX4 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>