======= TP53BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP53BP1
  * **<color #00a2e8>Official Name</color>**: tumor protein p53 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7158|7158]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12888|Q12888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP53BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP53BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:28241136}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|53-BP1 Tudor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin modification-dependent histone binding|
|DNA repair complex|
|cellular response to X-ray|
|negative regulation of double-strand break repair via homologous recombination|
|positive regulation of isotype switching|
|replication fork|
|telomeric DNA binding|
|response to X-ray|
|negative regulation of double-strand break repair|
|regulation of isotype switching|
|negative regulation of DNA repair|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of DNA recombination|
|positive regulation of immunoglobulin production|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|chromosome, telomeric region|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|RNA polymerase II activating transcription factor binding|
|damaged DNA binding|
|site of double-strand break|
|double-strand break repair via nonhomologous end joining|
|methylated histone binding|
|non-recombinational repair|
|regulation of immunoglobulin production|
|p53 binding|
|cellular response to ionizing radiation|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|transcription coregulator activity|
|condensed chromosome kinetochore|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of DNA recombination|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|nuclear chromosome, telomeric region|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|histone binding|
|DNA damage checkpoint|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|DNA integrity checkpoint|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to ionizing radiation|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|cellular response to radiation|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|positive regulation of immune effector process|
|regulation of response to DNA damage stimulus|
|positive regulation of DNA-binding transcription factor activity|
|nuclear body|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|protein homooligomerization|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|regulation of immune effector process|
|DNA repair|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|positive regulation of immune response|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.59|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.37|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.24|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.23|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.98|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.95|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.94|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.92|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.88|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.84|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.74|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.7|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.01|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.17|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.6|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.1|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5648
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP53BP1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>