======= TP73 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP73
  * **<color #00a2e8>Official Name</color>**: tumor protein p73
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7161|7161]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15350|O15350]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP73&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP73|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P53 tetramer|
|SAM 2|
|P53|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MDM2/MDM4 family protein binding|
|negative regulation of cardiac muscle cell proliferation|
|positive regulation of oligodendrocyte differentiation|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of heart growth|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|mismatch repair|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of oligodendrocyte differentiation|
|regulation of cardiac muscle cell proliferation|
|positive regulation of glial cell differentiation|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of muscle tissue development|
|regulation of cardiac muscle tissue growth|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of heart growth|
|p53 binding|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|regulation of hematopoietic stem cell differentiation|
|regulation of establishment of protein localization to mitochondrion|
|regulation of cardiac muscle tissue development|
|positive regulation of cell cycle arrest|
|regulation of membrane permeability|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of organ growth|
|negative regulation of developmental growth|
|regulation of cell cycle arrest|
|chromatin|
|positive regulation of mitochondrion organization|
|regulation of gliogenesis|
|regulation of stem cell differentiation|
|signal transduction by p53 class mediator|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|cell cycle arrest|
|intrinsic apoptotic signaling pathway|
|protein tetramerization|
|activation of MAPK activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of signal transduction by p53 class mediator|
|regulation of protein localization to membrane|
|mitochondrial transport|
|transcription regulatory region DNA binding|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|positive regulation of MAP kinase activity|
|kidney development|
|apoptotic signaling pathway|
|renal system development|
|positive regulation of cell cycle process|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|urogenital system development|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|regulation of developmental growth|
|transcription factor binding|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|positive regulation of neurogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell junction|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|viral process|
|negative regulation of cell differentiation|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|membrane organization|
|regulation of kinase activity|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.517|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7972
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP73 Expression in NALM6 Cells: 1.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>