======= TPH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPH2
  * **<color #00a2e8>Official Name</color>**: tryptophan hydroxylase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=121278|121278]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWU9|Q8IWU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Biopterin H|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tryptophan 5-monooxygenase activity|
|serotonin biosynthetic process|
|indolalkylamine biosynthetic process|
|primary amino compound biosynthetic process|
|indole-containing compound biosynthetic process|
|serotonin metabolic process|
|primary amino compound metabolic process|
|cellular response to lithium ion|
|indolalkylamine metabolic process|
|response to lithium ion|
|cellular biogenic amine biosynthetic process|
|indole-containing compound metabolic process|
|amine biosynthetic process|
|phenol-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|neurotransmitter biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|response to activity|
|amine metabolic process|
|response to estrogen|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|iron ion binding|
|circadian rhythm|
|response to glucocorticoid|
|response to calcium ion|
|response to corticosteroid|
|organic hydroxy compound biosynthetic process|
|cellular response to metal ion|
|ammonium ion metabolic process|
|cellular response to inorganic substance|
|rhythmic process|
|cellular amino acid metabolic process|
|neuron projection|
|response to steroid hormone|
|regulation of neurotransmitter levels|
|response to metal ion|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|response to inorganic substance|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.7|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.7|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPH2 Expression in NALM6 Cells: 3.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>