======= TRADD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRADD
  * **<color #00a2e8>Official Name</color>**: TNFRSF1A associated via death domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8717|8717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15628|Q15628]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRADD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRADD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|TRADD N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|death domain binding|
|death-inducing signaling complex|
|death-inducing signaling complex assembly|
|positive regulation of hair follicle development|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|positive regulation of hair cycle|
|regulation of hair follicle development|
|regulation of hair cycle|
|tumor necrosis factor receptor binding|
|extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of epidermis development|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of tumor necrosis factor-mediated signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of epidermis development|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|kinase binding|
|extrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|protein heterooligomerization|
|regulation of NIK/NF-kappaB signaling|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of inflammatory response|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of endopeptidase activity|
|regulation of response to cytokine stimulus|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidase activity|
|receptor complex|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|protein-containing complex binding|
|apoptotic signaling pathway|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|cytoskeleton|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|positive regulation of defense response|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|apoptotic process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.05|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRADD Expression in NALM6 Cells: 3.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>