======= TRAPPC10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC10
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7109|7109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48553|P48553]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAPPC10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPPII protein complex|
|early endosome to Golgi transport|
|TRAPP complex|
|intra-Golgi vesicle-mediated transport|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|retrograde transport, endosome to Golgi|
|vesicle budding from membrane|
|cytosolic transport|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|protein complex oligomerization|
|organelle localization|
|Golgi membrane|
|membrane organization|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|4.44|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|4.66|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|5.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab11a|RAB11A]]|0.538|
|[[:human genes:t:trappc9|TRAPPC9]]|0.535|
|[[:human genes:p:pitpnb|PITPNB]]|0.433|
|[[:human genes:i:insig1|INSIG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC10 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>