======= TRAPPC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC5
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126003|126003]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IUR0|Q8IUR0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAPP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPPI protein complex|
|TRAPPII protein complex|
|TRAPPIII protein complex|
|TRAPP complex|
|Rab guanyl-nucleotide exchange factor activity|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|organelle localization|
|Golgi membrane|
|membrane organization|
|endoplasmic reticulum|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.05|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.77|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps28|VPS28]]|0.439|
|[[:human genes:t:tsg101|TSG101]]|0.43|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 202/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|10/28|
|bone|6/26|
|breast|11/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|5/21|
|liver|3/20|
|lung|20/75|
|lymphocyte|9/16|
|ovary|7/26|
|pancreas|7/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|11/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 928
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC5 Expression in NALM6 Cells: 4.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>