======= TRDN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRDN
  * **<color #00a2e8>Official Name</color>**: triadin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10345|10345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13061|Q13061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRDN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRDN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation- contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Asp-B-Hydro N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell communication by electrical coupling involved in cardiac conduction|
|positive regulation of cell communication by electrical coupling|
|positive regulation of cardiac conduction|
|endoplasmic reticulum membrane organization|
|junctional membrane complex|
|regulation of cardiac muscle cell membrane potential|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|sarcoplasmic reticulum lumen|
|junctional sarcoplasmic reticulum membrane|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of cell communication by electrical coupling|
|sarcoplasmic reticulum calcium ion transport|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport into cytosol|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|negative regulation of calcium-mediated signaling|
|sarcoplasmic reticulum membrane|
|negative regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|negative regulation of cation channel activity|
|positive regulation of calcium-mediated signaling|
|sarcoplasmic reticulum|
|cytoplasmic microtubule organization|
|positive regulation of calcium ion transport into cytosol|
|release of sequestered calcium ion into cytosol|
|endoplasmic reticulum organization|
|negative regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|calcium ion transport into cytosol|
|regulation of release of sequestered calcium ion into cytosol|
|protein binding, bridging|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|heart process|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|ion channel binding|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|endomembrane system organization|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|microtubule-based process|
|response to bacterium|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|membrane organization|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|cytoskeleton organization|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.84|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.452|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16926
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRDN Expression in NALM6 Cells: -1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>