======= TRIAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIAP1
  * **<color #00a2e8>Official Name</color>**: TP53 regulated inhibitor of apoptosis 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51499|51499]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43715|O43715]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0203|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidic acid transfer activity|
|positive regulation of phospholipid transport|
|regulation of phospholipid transport|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of release of cytochrome c from mitochondria|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of anion transport|
|regulation of membrane lipid distribution|
|negative regulation of mitochondrion organization|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|positive regulation of lipid transport|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|p53 binding|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|mitochondrial intermembrane space|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|negative regulation of response to DNA damage stimulus|
|positive regulation of lipid localization|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to UV|
|negative regulation of cysteine-type endopeptidase activity|
|phospholipid transport|
|mitotic DNA damage checkpoint|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of anion transport|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|regulation of lipid transport|
|cellular response to light stimulus|
|signal transduction by p53 class mediator|
|organophosphate ester transport|
|DNA damage checkpoint|
|regulation of lipid localization|
|response to UV|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|cellular response to radiation|
|regulation of mitochondrion organization|
|regulation of signal transduction by p53 class mediator|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|negative regulation of cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of ion transport|
|positive regulation of cell cycle process|
|lipid transport|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|lipid localization|
|negative regulation of cell cycle process|
|negative regulation of proteolysis|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|response to radiation|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|organic anion transport|
|negative regulation of intracellular signal transduction|
|negative regulation of cell cycle|
|anion transport|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.14|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.06|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.01|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.98|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.95|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.94|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.93|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.92|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.9|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.89|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.89|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.83|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.81|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.8|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.76|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.74|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.73|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.71|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.73|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.79|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.85|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.86|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.87|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.88|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.92|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.94|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.95|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.95|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.96|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.01|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.03|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.05|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.05|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.08|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.08|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.1|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.13|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.22|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.22|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.23|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.26|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.35|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.39|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.44|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.52|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.54|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.55|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.6|
|[[:results:exp539|42°C R08 exp539]]|2.62|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.65|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.7|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.85|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.9|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.96|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|3.07|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.11|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.754|
|[[:human genes:c:crls1|CRLS1]]|0.717|
|[[:human genes:t:thg1l|THG1L]]|0.715|
|[[:human genes:d:dpagt1|DPAGT1]]|0.7|
|[[:human genes:r:romo1|ROMO1]]|0.7|
|[[:human genes:s:slc25a26|SLC25A26]]|0.698|
|[[:human genes:a:alg1|ALG1]]|0.693|
|[[:human genes:u:uap1|UAP1]]|0.681|
|[[:human genes:t:taz|TAZ]]|0.676|
|[[:human genes:r:rpe|RPE]]|0.673|
|[[:human genes:t:tamm41|TAMM41]]|0.661|
|[[:human genes:g:gmppb|GMPPB]]|0.651|
|[[:human genes:g:gfpt1|GFPT1]]|0.648|
|[[:human genes:h:hccs|HCCS]]|0.646|
|[[:human genes:d:dohh|DOHH]]|0.642|
|[[:human genes:s:srp14|SRP14]]|0.634|
|[[:human genes:r:rptor|RPTOR]]|0.63|
|[[:human genes:a:atxn10|ATXN10]]|0.628|
|[[:human genes:r:rtcb|RTCB]]|0.626|
|[[:human genes:h:hspd1|HSPD1]]|0.62|
|[[:human genes:v:vezt|VEZT]]|0.615|
|[[:human genes:r:rnmt|RNMT]]|0.607|
|[[:human genes:t:timm13|TIMM13]]|0.599|
|[[:human genes:t:trnt1|TRNT1]]|0.597|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.597|
|[[:human genes:c:casp9|CASP9]]|0.596|
|[[:human genes:p:pam16|PAM16]]|0.591|
|[[:human genes:a:alg5|ALG5]]|0.59|
|[[:human genes:a:alg13|ALG13]]|0.59|
|[[:human genes:d:dhps|DHPS]]|0.587|
|[[:human genes:n:nae1|NAE1]]|0.586|
|[[:human genes:o:opa1|OPA1]]|0.585|
|[[:human genes:a:atp5b|ATP5B]]|0.584|
|[[:human genes:a:atp5o|ATP5O]]|0.582|
|[[:human genes:p:pelo|PELO]]|0.582|
|[[:human genes:a:adsl|ADSL]]|0.581|
|[[:human genes:c:cycs|CYCS]]|0.581|
|[[:human genes:d:dnlz|DNLZ]]|0.581|
|[[:human genes:p:ppa2|PPA2]]|0.578|
|[[:human genes:p:plaa|PLAA]]|0.577|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.576|
|[[:human genes:u:utp23|UTP23]]|0.573|
|[[:human genes:a:apaf1|APAF1]]|0.572|
|[[:human genes:u:uhrf1|UHRF1]]|0.565|
|[[:human genes:a:atp5j|ATP5J]]|0.565|
|[[:human genes:r:rpia|RPIA]]|0.564|
|[[:human genes:c:chchd4|CHCHD4]]|0.564|
|[[:human genes:e:eny2|ENY2]]|0.564|
|[[:human genes:a:alg6|ALG6]]|0.56|
|[[:human genes:a:aars|AARS]]|0.559|
|[[:human genes:m:mrps34|MRPS34]]|0.556|
|[[:human genes:e:exoc4|EXOC4]]|0.555|
|[[:human genes:c:cbfb|CBFB]]|0.555|
|[[:human genes:a:atp5a1|ATP5A1]]|0.555|
|[[:human genes:b:bap1|BAP1]]|0.553|
|[[:human genes:m:mrps14|MRPS14]]|0.552|
|[[:human genes:t:trmt10a|TRMT10A]]|0.545|
|[[:human genes:t:tmem41b|TMEM41B]]|0.542|
|[[:human genes:m:meaf6|MEAF6]]|0.541|
|[[:human genes:d:dap3|DAP3]]|0.54|
|[[:human genes:h:hars|HARS]]|0.54|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.54|
|[[:human genes:p:ppcs|PPCS]]|0.538|
|[[:human genes:m:mrps16|MRPS16]]|0.538|
|[[:human genes:a:atp5h|ATP5H]]|0.537|
|[[:human genes:b:bak1|BAK1]]|0.535|
|[[:human genes:u:ube2g2|UBE2G2]]|0.535|
|[[:human genes:w:wdr24|WDR24]]|0.535|
|[[:human genes:t:trmt5|TRMT5]]|0.534|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.534|
|[[:human genes:l:lsm10|LSM10]]|0.533|
|[[:human genes:a:alg14|ALG14]]|0.532|
|[[:human genes:c:csnk2b|CSNK2B]]|0.532|
|[[:human genes:c:cox16|COX16]]|0.532|
|[[:human genes:a:atic|ATIC]]|0.532|
|[[:human genes:m:med16|MED16]]|0.532|
|[[:human genes:d:dad1|DAD1]]|0.531|
|[[:human genes:k:kdsr|KDSR]]|0.529|
|[[:human genes:z:zrsr2|ZRSR2]]|0.527|
|[[:human genes:p:pdss1|PDSS1]]|0.527|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.526|
|[[:human genes:y:yars2|YARS2]]|0.525|
|[[:human genes:c:cep57|CEP57]]|0.524|
|[[:human genes:m:mrpl21|MRPL21]]|0.523|
|[[:human genes:s:sec61g|SEC61G]]|0.523|
|[[:human genes:d:dhrsx|DHRSX]]|0.523|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.521|
|[[:human genes:s:sec62|SEC62]]|0.52|
|[[:human genes:b:bcs1l|BCS1L]]|0.52|
|[[:human genes:p:pgm3|PGM3]]|0.52|
|[[:human genes:m:mrps11|MRPS11]]|0.519|
|[[:human genes:e:eno1|ENO1]]|0.518|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.518|
|[[:human genes:a:atp5d|ATP5D]]|0.515|
|[[:human genes:r:rpp21|RPP21]]|0.515|
|[[:human genes:t:tbca|TBCA]]|0.514|
|[[:human genes:m:mtor|MTOR]]|0.514|
|[[:human genes:a:alg2|ALG2]]|0.514|
|[[:human genes:t:ten1|TEN1]]|0.514|
|[[:human genes:o:oraov1|ORAOV1]]|0.513|
|[[:human genes:d:dolk|DOLK]]|0.513|
|[[:human genes:f:fh|FH]]|0.513|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.513|
|[[:human genes:d:dpf2|DPF2]]|0.511|
|[[:human genes:t:txnl4b|TXNL4B]]|0.509|
|[[:human genes:t:tsen54|TSEN54]]|0.508|
|[[:human genes:u:uba3|UBA3]]|0.508|
|[[:human genes:e:elac2|ELAC2]]|0.508|
|[[:human genes:m:mrps18a|MRPS18A]]|0.507|
|[[:human genes:m:mrps6|MRPS6]]|0.503|
|[[:human genes:s:ssb|SSB]]|0.503|
|[[:human genes:m:mfn1|MFN1]]|0.502|
|[[:human genes:m:mrpl23|MRPL23]]|0.501|
|[[:human genes:t:tufm|TUFM]]|0.5|
|[[:human genes:s:sdha|SDHA]]|0.499|
|[[:human genes:c:cct7|CCT7]]|0.498|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.498|
|[[:human genes:t:thoc6|THOC6]]|0.498|
|[[:human genes:h:haus8|HAUS8]]|0.497|
|[[:human genes:v:vdac2|VDAC2]]|0.497|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.497|
|[[:human genes:n:nsd1|NSD1]]|0.497|
|[[:human genes:p:pggt1b|PGGT1B]]|0.497|
|[[:human genes:d:ddx55|DDX55]]|0.497|
|[[:human genes:t:tti2|TTI2]]|0.496|
|[[:human genes:t:tomm22|TOMM22]]|0.494|
|[[:human genes:d:dars2|DARS2]]|0.493|
|[[:human genes:m:mrpl15|MRPL15]]|0.493|
|[[:human genes:a:atp5f1|ATP5F1]]|0.493|
|[[:human genes:e:eif3f|EIF3F]]|0.491|
|[[:human genes:d:ddx20|DDX20]]|0.491|
|[[:human genes:u:ube2m|UBE2M]]|0.489|
|[[:human genes:p:pgs1|PGS1]]|0.488|
|[[:human genes:s:srd5a3|SRD5A3]]|0.488|
|[[:human genes:g:gfer|GFER]]|0.487|
|[[:human genes:s:serf2|SERF2]]|0.486|
|[[:human genes:y:yars|YARS]]|0.486|
|[[:human genes:r:rpusd4|RPUSD4]]|0.485|
|[[:human genes:t:txnrd1|TXNRD1]]|0.485|
|[[:human genes:m:mrps2|MRPS2]]|0.485|
|[[:human genes:r:rpn1|RPN1]]|0.483|
|[[:human genes:s:sars2|SARS2]]|0.481|
|[[:human genes:u:ube2k|UBE2K]]|0.481|
|[[:human genes:t:tmem242|TMEM242]]|0.48|
|[[:human genes:g:gemin8|GEMIN8]]|0.48|
|[[:human genes:t:tkt|TKT]]|0.479|
|[[:human genes:a:atp2a2|ATP2A2]]|0.479|
|[[:human genes:g:gfm1|GFM1]]|0.478|
|[[:human genes:t:tprkb|TPRKB]]|0.478|
|[[:human genes:p:ppp5c|PPP5C]]|0.477|
|[[:human genes:t:trmt61a|TRMT61A]]|0.477|
|[[:human genes:r:rad1|RAD1]]|0.477|
|[[:human genes:n:nupl2|NUPL2]]|0.476|
|[[:human genes:f:fnta|FNTA]]|0.475|
|[[:human genes:m:mrpl47|MRPL47]]|0.475|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.475|
|[[:human genes:f:faf2|FAF2]]|0.474|
|[[:human genes:o:oip5|OIP5]]|0.474|
|[[:human genes:m:mrpl20|MRPL20]]|0.474|
|[[:human genes:r:rft1|RFT1]]|0.474|
|[[:human genes:s:sco2|SCO2]]|0.473|
|[[:human genes:g:gemin7|GEMIN7]]|0.473|
|[[:human genes:b:brwd1|BRWD1]]|0.473|
|[[:human genes:g:gemin5|GEMIN5]]|0.472|
|[[:human genes:v:vrk1|VRK1]]|0.472|
|[[:human genes:n:nsmce1|NSMCE1]]|0.471|
|[[:human genes:m:mrps33|MRPS33]]|0.471|
|[[:human genes:p:parl|PARL]]|0.47|
|[[:human genes:w:wdr59|WDR59]]|0.47|
|[[:human genes:p:polr3h|POLR3H]]|0.47|
|[[:human genes:p:pik3r4|PIK3R4]]|0.47|
|[[:human genes:c:coq3|COQ3]]|0.467|
|[[:human genes:e:eif4e|EIF4E]]|0.467|
|[[:human genes:e:exoc3|EXOC3]]|0.467|
|[[:human genes:t:telo2|TELO2]]|0.466|
|[[:human genes:d:ddost|DDOST]]|0.466|
|[[:human genes:g:gnb1l|GNB1L]]|0.466|
|[[:human genes:c:ccdc101|CCDC101]]|0.466|
|[[:human genes:u:ubqln1|UBQLN1]]|0.466|
|[[:human genes:g:gemin6|GEMIN6]]|0.465|
|[[:human genes:s:slc35b1|SLC35B1]]|0.465|
|[[:human genes:m:mrp63|MRP63]]|0.465|
|[[:human genes:v:vmp1|VMP1]]|0.464|
|[[:human genes:c:c17orf89|C17orf89]]|0.464|
|[[:human genes:a:atp5l|ATP5L]]|0.464|
|[[:human genes:m:mbtps2|MBTPS2]]|0.464|
|[[:human genes:t:ttc4|TTC4]]|0.464|
|[[:human genes:r:rbfa|RBFA]]|0.462|
|[[:human genes:h:hars2|HARS2]]|0.462|
|[[:human genes:t:tgs1|TGS1]]|0.462|
|[[:human genes:c:cbx3|CBX3]]|0.461|
|[[:human genes:m:med23|MED23]]|0.461|
|[[:human genes:m:mrps9|MRPS9]]|0.46|
|[[:human genes:a:atp5c1|ATP5C1]]|0.458|
|[[:human genes:d:dr1|DR1]]|0.457|
|[[:human genes:m:mrps5|MRPS5]]|0.457|
|[[:human genes:m:march5|MARCH5]]|0.457|
|[[:human genes:v:vars2|VARS2]]|0.456|
|[[:human genes:c:coq5|COQ5]]|0.456|
|[[:human genes:p:phb|PHB]]|0.455|
|[[:human genes:f:fastkd5|FASTKD5]]|0.455|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.455|
|[[:human genes:t:timm23b|TIMM23B]]|0.454|
|[[:human genes:m:mrps26|MRPS26]]|0.454|
|[[:human genes:r:rbmx2|RBMX2]]|0.454|
|[[:human genes:l:lsm11|LSM11]]|0.454|
|[[:human genes:c:c11orf57|C11orf57]]|0.453|
|[[:human genes:u:uqcrq|UQCRQ]]|0.452|
|[[:human genes:r:rabggtb|RABGGTB]]|0.451|
|[[:human genes:p:pnpt1|PNPT1]]|0.451|
|[[:human genes:t:tbcb|TBCB]]|0.451|
|[[:human genes:k:kctd5|KCTD5]]|0.45|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.45|
|[[:human genes:t:timm22|TIMM22]]|0.449|
|[[:human genes:s:slc25a19|SLC25A19]]|0.449|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.449|
|[[:human genes:t:tars2|TARS2]]|0.448|
|[[:human genes:s:selrc1|SELRC1]]|0.447|
|[[:human genes:u:uxt|UXT]]|0.447|
|[[:human genes:m:mrpl53|MRPL53]]|0.447|
|[[:human genes:t:timm8b|TIMM8B]]|0.447|
|[[:human genes:g:gatc|GATC]]|0.446|
|[[:human genes:a:atp5i|ATP5I]]|0.446|
|[[:human genes:n:nars|NARS]]|0.446|
|[[:human genes:g:gfm2|GFM2]]|0.445|
|[[:human genes:n:nup50|NUP50]]|0.444|
|[[:human genes:e:eprs|EPRS]]|0.443|
|[[:human genes:t:tomm40|TOMM40]]|0.443|
|[[:human genes:o:otud5|OTUD5]]|0.443|
|[[:human genes:l:lonp1|LONP1]]|0.443|
|[[:human genes:w:wbscr16|WBSCR16]]|0.443|
|[[:human genes:p:pars2|PARS2]]|0.442|
|[[:human genes:c:cox7b|COX7B]]|0.441|
|[[:human genes:t:tti1|TTI1]]|0.44|
|[[:human genes:m:mis18a|MIS18A]]|0.439|
|[[:human genes:c:c12orf65|C12orf65]]|0.439|
|[[:human genes:m:med4|MED4]]|0.439|
|[[:human genes:e:ears2|EARS2]]|0.438|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.438|
|[[:human genes:m:metap2|METAP2]]|0.438|
|[[:human genes:t:top3a|TOP3A]]|0.437|
|[[:human genes:m:mrpl27|MRPL27]]|0.436|
|[[:human genes:p:pisd|PISD]]|0.436|
|[[:human genes:s:stt3a|STT3A]]|0.434|
|[[:human genes:t:tbp|TBP]]|0.434|
|[[:human genes:e:elf2|ELF2]]|0.432|
|[[:human genes:c:cox17|COX17]]|0.432|
|[[:human genes:m:mapk14|MAPK14]]|0.432|
|[[:human genes:r:rars2|RARS2]]|0.431|
|[[:human genes:w:wdr1|WDR1]]|0.431|
|[[:human genes:g:gabpa|GABPA]]|0.431|
|[[:human genes:z:zfp91|ZFP91]]|0.431|
|[[:human genes:s:sec16a|SEC16A]]|0.431|
|[[:human genes:g:gtf3a|GTF3A]]|0.43|
|[[:human genes:m:mrps21|MRPS21]]|0.43|
|[[:human genes:c:c10orf2|C10orf2]]|0.429|
|[[:human genes:p:ppp4c|PPP4C]]|0.429|
|[[:human genes:t:tmed10|TMED10]]|0.428|
|[[:human genes:n:nbn|NBN]]|0.428|
|[[:human genes:d:diablo|DIABLO]]|0.426|
|[[:human genes:s:sec63|SEC63]]|0.426|
|[[:human genes:d:dhx30|DHX30]]|0.425|
|[[:human genes:u:ube2j1|UBE2J1]]|0.425|
|[[:human genes:t:tsen34|TSEN34]]|0.425|
|[[:human genes:m:mllt1|MLLT1]]|0.424|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.424|
|[[:human genes:n:nxt1|NXT1]]|0.424|
|[[:human genes:d:dusp12|DUSP12]]|0.422|
|[[:human genes:s:srp68|SRP68]]|0.421|
|[[:human genes:d:ddx1|DDX1]]|0.421|
|[[:human genes:e:eef1e1|EEF1E1]]|0.42|
|[[:human genes:m:mrpl36|MRPL36]]|0.419|
|[[:human genes:a:asxl2|ASXL2]]|0.419|
|[[:human genes:c:cars|CARS]]|0.418|
|[[:human genes:t:tpk1|TPK1]]|0.417|
|[[:human genes:e:elp3|ELP3]]|0.417|
|[[:human genes:s:srp72|SRP72]]|0.416|
|[[:human genes:u:urm1|URM1]]|0.416|
|[[:human genes:t:trim28|TRIM28]]|0.416|
|[[:human genes:f:fbxo11|FBXO11]]|0.415|
|[[:human genes:m:mars|MARS]]|0.415|
|[[:human genes:a:alg8|ALG8]]|0.415|
|[[:human genes:t:tefm|TEFM]]|0.415|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.414|
|[[:human genes:w:wdr92|WDR92]]|0.414|
|[[:human genes:b:btf3|BTF3]]|0.413|
|[[:human genes:m:mrps23|MRPS23]]|0.412|
|[[:human genes:d:dnajc3|DNAJC3]]|0.412|
|[[:human genes:r:rfk|RFK]]|0.411|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.41|
|[[:human genes:c:chordc1|CHORDC1]]|0.409|
|[[:human genes:u:uqcr10|UQCR10]]|0.408|
|[[:human genes:u:uba5|UBA5]]|0.407|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.407|
|[[:human genes:p:pdap1|PDAP1]]|0.406|
|[[:human genes:t:tpi1|TPI1]]|0.406|
|[[:human genes:n:ndufb5|NDUFB5]]|0.406|
|[[:human genes:c:ctc1|CTC1]]|0.406|
|[[:human genes:e:elp2|ELP2]]|0.405|
|[[:human genes:s:spcs2|SPCS2]]|0.404|
|[[:human genes:o:osgep|OSGEP]]|0.404|
|[[:human genes:t:taf1a|TAF1A]]|0.404|
|[[:human genes:t:tmem126b|TMEM126B]]|0.403|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.403|
|[[:human genes:c:cdipt|CDIPT]]|0.403|
|[[:human genes:s:slmo2|SLMO2]]|0.403|
|[[:human genes:d:dhx29|DHX29]]|0.402|
|[[:human genes:m:mrpl34|MRPL34]]|0.402|
|[[:human genes:z:zfx|ZFX]]|0.401|
|[[:human genes:g:glmn|GLMN]]|0.401|
|[[:human genes:p:polr3b|POLR3B]]|0.401|
|[[:human genes:p:pdpk1|PDPK1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 700/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|25/26|
|breast|29/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|19/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIAP1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>