======= TRIM25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM25
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7706|7706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14258|Q14258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). {ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ligase activity|
|negative regulation of viral release from host cell|
|negative regulation of viral entry into host cell|
|regulation of viral entry into host cell|
|response to vitamin D|
|regulation of viral release from host cell|
|translesion synthesis|
|negative regulation of type I interferon production|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|protein monoubiquitination|
|ubiquitin-dependent ERAD pathway|
|interferon-gamma-mediated signaling pathway|
|response to estrogen|
|negative regulation of viral life cycle|
|response to vitamin|
|ERAD pathway|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|negative regulation of viral process|
|DNA biosynthetic process|
|regulation of type I interferon production|
|regulation of viral life cycle|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|defense response to virus|
|regulation of viral process|
|response to nutrient|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ubiquitin protein ligase activity|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cytokine production|
|response to virus|
|nuclear body|
|cadherin binding|
|negative regulation of locomotion|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|response to nutrient levels|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulation of cytokine production|
|viral process|
|DNA metabolic process|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|response to lipid|
|cellular macromolecule catabolic process|
|response to organic cyclic compound|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|proteolysis|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.426|
|[[:human genes:c:casp3|CASP3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM25 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>