======= TRIM27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM27
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5987|5987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14373|P14373]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-2 secretion|
|regulation of interleukin-2 secretion|
|negative regulation of calcium ion import|
|interferon-gamma secretion|
|positive regulation of actin nucleation|
|negative regulation of viral release from host cell|
|interferon-gamma production|
|retromer complex|
|Arp2/3 complex-mediated actin nucleation|
|negative regulation of interleukin-2 production|
|negative regulation of viral transcription|
|regulation of actin nucleation|
|regulation of viral release from host cell|
|actin nucleation|
|regulation of calcium ion import|
|protein K63-linked ubiquitination|
|negative regulation of adaptive immune response|
|cytokine secretion|
|protein trimerization|
|regulation of interleukin-2 production|
|negative regulation of tumor necrosis factor production|
|negative regulation of calcium ion transport|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of viral transcription|
|negative regulation of cytokine secretion|
|negative regulation of viral life cycle|
|negative regulation of gene expression, epigenetic|
|positive regulation of actin filament polymerization|
|retrograde transport, endosome to Golgi|
|negative regulation of viral process|
|PML body|
|positive regulation of protein polymerization|
|negative regulation of protein secretion|
|fibrillar center|
|negative regulation of peptide secretion|
|regulation of viral life cycle|
|cytosolic transport|
|negative regulation of ion transport|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|regulation of actin filament polymerization|
|protein localization to extracellular region|
|peptide secretion|
|negative regulation of protein transport|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|negative regulation of establishment of protein localization|
|nucleic acid binding|
|positive regulation of supramolecular fiber organization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|positive regulation of cytoskeleton organization|
|ubiquitin protein ligase activity|
|regulation of protein polymerization|
|negative regulation of protein kinase activity|
|endosomal transport|
|negative regulation of secretion|
|regulation of gene expression, epigenetic|
|nuclear membrane|
|actin filament organization|
|negative regulation of kinase activity|
|ubiquitin-protein transferase activity|
|regulation of calcium ion transport|
|positive regulation of protein complex assembly|
|early endosome|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|endosome|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|protein polyubiquitination|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|actin filament-based process|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|protein ubiquitination|
|gamete generation|
|regulation of cytokine production|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|secretion by cell|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|identical protein binding|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.78|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16170
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM27 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>