======= TRIM46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM46
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 46
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80128|80128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4K8|Q7Z4K8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600986|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of dense core granule transport|
|regulation of anterograde dense core granule transport|
|positive regulation of anterograde dense core granule transport|
|positive regulation of dense core granule transport|
|positive regulation of vesicle transport along microtubule|
|proximal neuron projection|
|regulation of vesicle transport along microtubule|
|main axon|
|protein localization to axon|
|regulation of organelle transport along microtubule|
|positive regulation of cytoplasmic transport|
|synaptic vesicle transport along microtubule|
|synaptic vesicle cytoskeletal transport|
|anterograde synaptic vesicle transport|
|axon initial segment|
|regulation of cytoplasmic transport|
|regulation of microtubule-based movement|
|synaptic vesicle transport|
|synaptic vesicle localization|
|negative regulation of axon extension|
|vesicle transport along microtubule|
|anterograde axonal transport|
|vesicle cytoskeletal trafficking|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|negative regulation of axonogenesis|
|organelle transport along microtubule|
|microtubule bundle formation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|neuron migration|
|negative regulation of neuron projection development|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|regulation of cell size|
|negative regulation of cell projection organization|
|microtubule-based transport|
|negative regulation of cell growth|
|vesicle localization|
|regulation of axonogenesis|
|positive regulation of intracellular transport|
|regulation of microtubule-based process|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|microtubule-based movement|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of intracellular transport|
|establishment of organelle localization|
|cytoskeleton|
|axonogenesis|
|regulation of cellular component size|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cell morphogenesis involved in differentiation|
|organelle localization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.09|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.75|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6184
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM46 Expression in NALM6 Cells: 1.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>