======= TRIM52 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM52
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 52
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84851|84851]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A61|Q96A61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM52&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM52|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of DNA-binding transcription factor activity|
|nuclear body|
|regulation of DNA-binding transcription factor activity|
|zinc ion binding|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.75|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.41|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.11|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.99|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.92|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.92|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.83|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.82|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.73|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.74|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.75|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.75|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.81|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.83|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.88|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.95|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.97|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.02|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.02|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.08|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.15|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.27|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.27|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.34|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.39|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.4|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.44|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.57|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.95|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.493|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.486|
|[[:human genes:r:rbbp5|RBBP5]]|0.483|
|[[:human genes:c:cdc73|CDC73]]|0.482|
|[[:human genes:m:myo1h|MYO1H]]|0.475|
|[[:human genes:c:ckap5|CKAP5]]|0.473|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.472|
|[[:human genes:s:ssh2|SSH2]]|0.472|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.47|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.463|
|[[:human genes:c:cgb2|CGB2]]|0.463|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.458|
|[[:human genes:c:cope|COPE]]|0.458|
|[[:human genes:m:myt1l|MYT1L]]|0.457|
|[[:human genes:s:s1pr4|S1PR4]]|0.452|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.452|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.449|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.449|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.449|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.449|
|[[:human genes:n:npipb8|NPIPB8]]|0.447|
|[[:human genes:s:sec13|SEC13]]|0.447|
|[[:human genes:v:vasn|VASN]]|0.445|
|[[:human genes:r:rps9|RPS9]]|0.443|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.443|
|[[:human genes:r:rrn3|RRN3]]|0.437|
|[[:human genes:n:npipb5|NPIPB5]]|0.432|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.431|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.43|
|[[:human genes:d:ddx56|DDX56]]|0.429|
|[[:human genes:s:snrpa1|SNRPA1]]|0.428|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.427|
|[[:human genes:c:chd4|CHD4]]|0.426|
|[[:human genes:p:plk4|PLK4]]|0.425|
|[[:human genes:p:pola1|POLA1]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.422|
|[[:human genes:m:myo18a|MYO18A]]|0.421|
|[[:human genes:z:znf219|ZNF219]]|0.42|
|[[:human genes:p:psap|PSAP]]|0.417|
|[[:human genes:a:aqr|AQR]]|0.416|
|[[:human genes:n:ndc80|NDC80]]|0.416|
|[[:human genes:c:cwc22|CWC22]]|0.412|
|[[:human genes:a:atxn1|ATXN1]]|0.412|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:r:rfxank|RFXANK]]|0.411|
|[[:human genes:r:rrp15|RRP15]]|0.411|
|[[:human genes:t:tceb3c|TCEB3C]]|0.41|
|[[:human genes:r:rps6|RPS6]]|0.41|
|[[:human genes:n:nop16|NOP16]]|0.41|
|[[:human genes:g:golga8o|GOLGA8O]]|0.409|
|[[:human genes:c:ccna2|CCNA2]]|0.408|
|[[:human genes:a:ahctf1|AHCTF1]]|0.407|
|[[:human genes:p:psmb4|PSMB4]]|0.406|
|[[:human genes:e:exosc5|EXOSC5]]|0.406|
|[[:human genes:r:rps20|RPS20]]|0.406|
|[[:human genes:w:wdr87|WDR87]]|0.403|
|[[:human genes:p:psmd11|PSMD11]]|0.401|
|[[:human genes:t:tfip11|TFIP11]]|0.401|
|[[:human genes:m:madcam1|MADCAM1]]|0.401|
|[[:human genes:k:krt78|KRT78]]|0.401|
|[[:human genes:p:paf1|PAF1]]|0.4|
|[[:human genes:d:dtl|DTL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1540
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM52 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>