======= TRIM54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM54
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 54
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57159|57159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYV2|Q9BYV2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May bind and stabilize microtubules during myotubes formation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|microtubule associated complex|
|negative regulation of microtubule polymerization or depolymerization|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|Z disc|
|negative regulation of cytoskeleton organization|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|microtubule binding|
|microtubule|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cytoskeleton organization|
|microtubule-based process|
|negative regulation of cellular component organization|
|zinc ion binding|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.27|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.88|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.82|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.77|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.75|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.73|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.77|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.95|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.97|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM54 Expression in NALM6 Cells: -1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>