======= TRIM71 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM71
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 71
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131405|131405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2Q1W2|Q2Q1W2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM71&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM71|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250|UniProtKB:Q1PSW8, ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:28431233, ECO:0000305|PubMed:24239284}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NHL|
|zf-B box|
|Filamin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation repressor activity|
|miRNA mediated inhibition of translation|
|negative regulation of translation, ncRNA-mediated|
|regulation of translation, ncRNA-mediated|
|3-UTR-mediated mRNA destabilization|
|miRNA metabolic process|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|production of miRNAs involved in gene silencing by miRNA|
|mRNA destabilization|
|miRNA binding|
|RNA destabilization|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|gene silencing by miRNA|
|positive regulation of mRNA catabolic process|
|stem cell proliferation|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|protein autoubiquitination|
|positive regulation of mRNA metabolic process|
|fibroblast growth factor receptor signaling pathway|
|P-body|
|regulation of gene silencing by miRNA|
|gene silencing by RNA|
|regulation of neural precursor cell proliferation|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|embryonic epithelial tube formation|
|regulation of gene silencing|
|negative regulation of translation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|negative regulation of cellular amide metabolic process|
|tube formation|
|gene silencing|
|neural tube development|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|ubiquitin protein ligase activity|
|regulation of gene expression, epigenetic|
|ubiquitin-protein transferase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein polyubiquitination|
|epithelial tube morphogenesis|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of mRNA metabolic process|
|proteasomal protein catabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|ncRNA metabolic process|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|enzyme linked receptor protein signaling pathway|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|embryo development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|cellular response to endogenous stimulus|
|proteolysis|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.13|
|[[:results:exp302|35°C R06 exp302]]|-1.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.79|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.72|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.74|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM71 Expression in NALM6 Cells: 1.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>