======= TRIM8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM8
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81603|81603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZR9|Q9BZR9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which plays different roles in immune pathways. Participates in the activation of interferon- gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'lys-63' polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). {ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:20516148, ECO:0000269|PubMed:22084099, ECO:0000269|PubMed:23152791}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of viral release from host cell|
|negative regulation of viral entry into host cell|
|negative regulation of viral transcription|
|regulation of viral entry into host cell|
|regulation of viral release from host cell|
|transferase activity|
|regulation of viral transcription|
|interferon-gamma-mediated signaling pathway|
|positive regulation of protein localization to nucleus|
|negative regulation of viral life cycle|
|negative regulation of viral process|
|PML body|
|regulation of protein localization to nucleus|
|positive regulation of autophagy|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of viral life cycle|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of cellular protein localization|
|cytokine-mediated signaling pathway|
|protein ubiquitination|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|zinc ion binding|
|protein homodimerization activity|
|regulation of cellular localization|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|identical protein binding|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|3/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7882
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM8 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>