======= TRIT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIT1
  * **<color #00a2e8>Official Name</color>**: tRNA isopentenyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54802|54802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3H1|Q9H3H1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IPPT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA dimethylallyltransferase activity|
|mitochondrial RNA modification|
|mitochondrial tRNA modification|
|mitochondrial tRNA processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|mitochondrial RNA metabolic process|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|nucleic acid binding|
|mitochondrial matrix|
|ncRNA processing|
|cellular component|
|ncRNA metabolic process|
|zinc ion binding|
|RNA processing|
|mitochondrion|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.77|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.07|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.11|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.15|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.17|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.17|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.18|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.49|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmnd1|RMND1]]|0.464|
|[[:human genes:f:fastkd2|FASTKD2]]|0.461|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.448|
|[[:human genes:p:prepl|PREPL]]|0.445|
|[[:human genes:p:pet117|PET117]]|0.444|
|[[:human genes:w:wars2|WARS2]]|0.424|
|[[:human genes:m:mettl17|METTL17]]|0.419|
|[[:human genes:n:nsun4|NSUN4]]|0.416|
|[[:human genes:n:ndufv2|NDUFV2]]|0.415|
|[[:human genes:m:mrps27|MRPS27]]|0.412|
|[[:human genes:n:ndufs2|NDUFS2]]|0.409|
|[[:human genes:t:tfb1m|TFB1M]]|0.404|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.404|
|[[:human genes:t:tomm7|TOMM7]]|0.401|
|[[:human genes:n:ndufs5|NDUFS5]]|0.401|
|[[:human genes:d:ddx28|DDX28]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|3/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIT1 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>