======= TRMT112 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT112
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase subunit 11-2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51504|51504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI30|Q9UI30]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT112&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT112|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L- methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trm112p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (guanine-N7)-methylation|
|rRNA (guanine) methyltransferase activity|
|peptidyl-glutamine methylation|
|RNA (guanine-N7)-methylation|
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|protein methyltransferase activity|
|rRNA base methylation|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|rRNA methylation|
|rRNA modification|
|tRNA methylation|
|RNA methylation|
|tRNA modification|
|translational termination|
|tRNA processing|
|protein methylation|
|protein alkylation|
|cellular protein complex disassembly|
|RNA modification|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|protein-containing complex disassembly|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|translation|
|ncRNA processing|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein heterodimerization activity|
|positive regulation of cellular component biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|protein-containing complex|
|perinuclear region of cytoplasm|
|cellular amide metabolic process|
|RNA processing|
|regulation of cellular component biogenesis|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.76|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.74|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.72|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.72|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.71|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.71|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.77|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT112 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>