======= TRMT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT6
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51605|51605]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJA5|Q9UJA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620886|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gcd10p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA (m1A) methyltransferase complex|
|tRNA (adenine-N1-)-methyltransferase activity|
|mRNA methylation|
|mRNA modification|
|tRNA methylation|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|ncRNA metabolic process|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.73|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.73|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.78|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.87|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.91|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.91|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.93|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.03|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.06|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.45|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trmt61a|TRMT61A]]|0.628|
|[[:human genes:p:ppcdc|PPCDC]]|0.569|
|[[:human genes:d:dnlz|DNLZ]]|0.542|
|[[:human genes:d:dhrsx|DHRSX]]|0.52|
|[[:human genes:a:alg6|ALG6]]|0.517|
|[[:human genes:r:rpia|RPIA]]|0.507|
|[[:human genes:p:pmvk|PMVK]]|0.506|
|[[:human genes:l:lsm10|LSM10]]|0.495|
|[[:human genes:s:srd5a3|SRD5A3]]|0.486|
|[[:human genes:r:rft1|RFT1]]|0.471|
|[[:human genes:t:thg1l|THG1L]]|0.468|
|[[:human genes:d:dolk|DOLK]]|0.463|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.445|
|[[:human genes:t:ten1|TEN1]]|0.44|
|[[:human genes:p:ppcs|PPCS]]|0.436|
|[[:human genes:s:srp14|SRP14]]|0.43|
|[[:human genes:p:pgm3|PGM3]]|0.43|
|[[:human genes:m:mettl1|METTL1]]|0.427|
|[[:human genes:c:cep57|CEP57]]|0.424|
|[[:human genes:g:gemin7|GEMIN7]]|0.415|
|[[:human genes:f:fh|FH]]|0.415|
|[[:human genes:g:gemin8|GEMIN8]]|0.414|
|[[:human genes:c:c15orf41|C15orf41]]|0.414|
|[[:human genes:p:ppa1|PPA1]]|0.412|
|[[:human genes:a:alg8|ALG8]]|0.412|
|[[:human genes:a:alg1|ALG1]]|0.404|
|[[:human genes:t:trmt10a|TRMT10A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT6 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>