======= TRMT61A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT61A
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 61A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115708|115708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FX7|Q96FX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT61A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT61A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)- methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 18|
|GCD14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA (m1A) methyltransferase complex|
|mRNA (adenine-N1-)-methyltransferase activity|
|tRNA (adenine-N1-)-methyltransferase activity|
|mRNA methylation|
|mRNA modification|
|tRNA methylation|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|ncRNA metabolic process|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.13|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.01|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.89|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.79|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.8|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.8|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.82|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.85|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.87|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.92|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.98|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.04|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.06|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.08|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.12|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.22|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.24|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.3|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.33|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.39|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.39|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.56|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.57|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.57|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.65|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.8|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnlz|DNLZ]]|0.645|
|[[:human genes:d:dhrsx|DHRSX]]|0.637|
|[[:human genes:t:trmt6|TRMT6]]|0.628|
|[[:human genes:p:pmvk|PMVK]]|0.614|
|[[:human genes:p:ppcdc|PPCDC]]|0.613|
|[[:human genes:m:mettl1|METTL1]]|0.596|
|[[:human genes:t:ten1|TEN1]]|0.594|
|[[:human genes:r:rft1|RFT1]]|0.587|
|[[:human genes:t:thg1l|THG1L]]|0.586|
|[[:human genes:p:ppcs|PPCS]]|0.578|
|[[:human genes:p:pgm3|PGM3]]|0.576|
|[[:human genes:y:yars2|YARS2]]|0.571|
|[[:human genes:r:rpia|RPIA]]|0.571|
|[[:human genes:t:trmt10a|TRMT10A]]|0.552|
|[[:human genes:l:lsm10|LSM10]]|0.539|
|[[:human genes:f:fh|FH]]|0.538|
|[[:human genes:p:pars2|PARS2]]|0.534|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.526|
|[[:human genes:k:kdsr|KDSR]]|0.524|
|[[:human genes:m:mrps34|MRPS34]]|0.523|
|[[:human genes:e:ears2|EARS2]]|0.514|
|[[:human genes:s:srd5a3|SRD5A3]]|0.513|
|[[:human genes:a:alg6|ALG6]]|0.512|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.512|
|[[:human genes:d:dap3|DAP3]]|0.505|
|[[:human genes:r:romo1|ROMO1]]|0.504|
|[[:human genes:t:tmem242|TMEM242]]|0.499|
|[[:human genes:g:gatc|GATC]]|0.498|
|[[:human genes:d:dohh|DOHH]]|0.498|
|[[:human genes:t:tpk1|TPK1]]|0.493|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.493|
|[[:human genes:v:vezt|VEZT]]|0.492|
|[[:human genes:p:ptar1|PTAR1]]|0.491|
|[[:human genes:s:ssb|SSB]]|0.49|
|[[:human genes:a:atic|ATIC]]|0.486|
|[[:human genes:m:mrps5|MRPS5]]|0.486|
|[[:human genes:d:dolk|DOLK]]|0.482|
|[[:human genes:t:triap1|TRIAP1]]|0.477|
|[[:human genes:c:c17orf89|C17orf89]]|0.477|
|[[:human genes:p:polg|POLG]]|0.477|
|[[:human genes:d:dr1|DR1]]|0.476|
|[[:human genes:p:pgs1|PGS1]]|0.475|
|[[:human genes:d:dars2|DARS2]]|0.472|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.471|
|[[:human genes:m:mrpl23|MRPL23]]|0.47|
|[[:human genes:p:pmm2|PMM2]]|0.467|
|[[:human genes:a:alg1|ALG1]]|0.467|
|[[:human genes:m:msto1|MSTO1]]|0.466|
|[[:human genes:r:rpp21|RPP21]]|0.465|
|[[:human genes:p:ppa1|PPA1]]|0.465|
|[[:human genes:b:bcs1l|BCS1L]]|0.465|
|[[:human genes:m:mrpl21|MRPL21]]|0.463|
|[[:human genes:g:g6pd|G6PD]]|0.462|
|[[:human genes:a:adat3|ADAT3]]|0.462|
|[[:human genes:s:sec62|SEC62]]|0.457|
|[[:human genes:p:pdap1|PDAP1]]|0.454|
|[[:human genes:l:lars2|LARS2]]|0.453|
|[[:human genes:s:srp14|SRP14]]|0.453|
|[[:human genes:a:atxn10|ATXN10]]|0.452|
|[[:human genes:d:dcps|DCPS]]|0.451|
|[[:human genes:g:gemin7|GEMIN7]]|0.45|
|[[:human genes:t:tars2|TARS2]]|0.45|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.449|
|[[:human genes:m:mrps16|MRPS16]]|0.449|
|[[:human genes:t:ttc4|TTC4]]|0.448|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.446|
|[[:human genes:m:mbtps2|MBTPS2]]|0.444|
|[[:human genes:s:slc25a26|SLC25A26]]|0.444|
|[[:human genes:s:sco2|SCO2]]|0.444|
|[[:human genes:a:alg8|ALG8]]|0.444|
|[[:human genes:u:uap1|UAP1]]|0.442|
|[[:human genes:m:mrps14|MRPS14]]|0.441|
|[[:human genes:d:ddx39a|DDX39A]]|0.438|
|[[:human genes:g:gemin6|GEMIN6]]|0.436|
|[[:human genes:m:mrpl53|MRPL53]]|0.434|
|[[:human genes:h:hars2|HARS2]]|0.434|
|[[:human genes:p:pitrm1|PITRM1]]|0.433|
|[[:human genes:d:dpagt1|DPAGT1]]|0.433|
|[[:human genes:s:selrc1|SELRC1]]|0.432|
|[[:human genes:r:rfk|RFK]]|0.431|
|[[:human genes:c:cep57|CEP57]]|0.43|
|[[:human genes:u:urm1|URM1]]|0.429|
|[[:human genes:n:nars2|NARS2]]|0.428|
|[[:human genes:g:gemin8|GEMIN8]]|0.427|
|[[:human genes:m:mocs3|MOCS3]]|0.427|
|[[:human genes:e:eef1e1|EEF1E1]]|0.426|
|[[:human genes:m:mrps18a|MRPS18A]]|0.425|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.424|
|[[:human genes:v:vars2|VARS2]]|0.424|
|[[:human genes:p:ppp6c|PPP6C]]|0.423|
|[[:human genes:m:mrps6|MRPS6]]|0.422|
|[[:human genes:m:mrps21|MRPS21]]|0.421|
|[[:human genes:w:wars2|WARS2]]|0.421|
|[[:human genes:a:aars2|AARS2]]|0.419|
|[[:human genes:m:mrps26|MRPS26]]|0.419|
|[[:human genes:p:ppa2|PPA2]]|0.418|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.418|
|[[:human genes:t:tubd1|TUBD1]]|0.417|
|[[:human genes:g:gfm2|GFM2]]|0.415|
|[[:human genes:a:atp2a2|ATP2A2]]|0.412|
|[[:human genes:n:n6amt1|N6AMT1]]|0.41|
|[[:human genes:i:iba57|IBA57]]|0.408|
|[[:human genes:m:mre11a|MRE11A]]|0.408|
|[[:human genes:c:chchd4|CHCHD4]]|0.407|
|[[:human genes:q:qrsl1|QRSL1]]|0.407|
|[[:human genes:r:rptor|RPTOR]]|0.406|
|[[:human genes:z:zcrb1|ZCRB1]]|0.406|
|[[:human genes:r:rbfa|RBFA]]|0.406|
|[[:human genes:s:slc7a1|SLC7A1]]|0.405|
|[[:human genes:u:uqcr10|UQCR10]]|0.405|
|[[:human genes:t:tsen54|TSEN54]]|0.405|
|[[:human genes:m:mipep|MIPEP]]|0.405|
|[[:human genes:c:c15orf41|C15orf41]]|0.404|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.404|
|[[:human genes:m:mrps2|MRPS2]]|0.403|
|[[:human genes:r:rpusd4|RPUSD4]]|0.403|
|[[:human genes:a:agpat2|AGPAT2]]|0.403|
|[[:human genes:g:gnpnat1|GNPNAT1]]|0.402|
|[[:human genes:t:tube1|TUBE1]]|0.402|
|[[:human genes:t:tefm|TEFM]]|0.402|
|[[:human genes:o:obfc1|OBFC1]]|0.402|
|[[:human genes:a:atp5d|ATP5D]]|0.401|
|[[:human genes:t:tomm20|TOMM20]]|0.4|
|[[:human genes:o:opa1|OPA1]]|0.4|
|[[:human genes:d:dpm3|DPM3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 340
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT61A Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>