======= TRPC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPC6
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily C member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7225|7225]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y210|Q9Y210]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603652|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|TRP 2|
|Ion trans|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|slit diaphragm|
|cation channel complex|
|store-operated calcium channel activity|
|actinin binding|
|manganese ion transport|
|inositol 1,4,5 trisphosphate binding|
|negative regulation of dendrite morphogenesis|
|cation channel activity|
|negative regulation of dendrite development|
|positive regulation of peptidyl-threonine phosphorylation|
|clathrin binding|
|regulation of peptidyl-threonine phosphorylation|
|cellular response to hydrogen peroxide|
|ATPase binding|
|regulation of dendrite morphogenesis|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|transition metal ion transport|
|positive regulation of calcium ion transport|
|cellular response to reactive oxygen species|
|platelet activation|
|single fertilization|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|positive regulation of ion transmembrane transport|
|fertilization|
|negative regulation of cell projection organization|
|cellular response to hypoxia|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|negative regulation of neuron differentiation|
|cellular response to oxidative stress|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|actin binding|
|positive regulation of ion transport|
|regulation of transporter activity|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of neurogenesis|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|response to antibiotic|
|negative regulation of nervous system development|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|response to oxygen levels|
|response to oxidative stress|
|regulation of metal ion transport|
|cellular response to drug|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|wound healing|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|regulation of body fluid levels|
|response to toxic substance|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|response to wounding|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of neurogenesis|
|cation transport|
|sexual reproduction|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|positive regulation of transport|
|multi-organism reproductive process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPC6 Expression in NALM6 Cells: -0.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>