======= TRPM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPM4
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily M member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54795|54795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TD43|Q8TD43]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606936|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of regulation of vascular smooth muscle cell membrane depolarization|
|positive regulation of atrial cardiac muscle cell action potential|
|positive regulation of cardiac conduction|
|membrane depolarization during bundle of His cell action potential|
|Purkinje myocyte action potential|
|membrane depolarization during Purkinje myocyte cell action potential|
|positive regulation of cardiac muscle cell contraction|
|positive regulation of actin filament-based movement|
|Purkinje myocyte to ventricular cardiac muscle cell signaling|
|membrane depolarization during AV node cell action potential|
|bundle of His cell action potential|
|bundle of His cell to Purkinje myocyte signaling|
|sodium channel complex|
|positive regulation of adipose tissue development|
|Purkinje myocyte to ventricular cardiac muscle cell communication|
|regulation of atrial cardiac muscle cell action potential|
|spanning component of plasma membrane|
|spanning component of membrane|
|AV node cell to bundle of His cell signaling|
|AV node cell action potential|
|regulation of adipose tissue development|
|positive regulation of action potential|
|AV node cell to bundle of His cell communication|
|positive regulation of cardiac muscle contraction|
|positive regulation of membrane depolarization|
|bundle of His cell to Purkinje myocyte communication|
|calcium activated cation channel activity|
|positive regulation of striated muscle contraction|
|regulation of ventricular cardiac muscle cell action potential|
|sodium ion import across plasma membrane|
|membrane depolarization during cardiac muscle cell action potential|
|dendritic cell chemotaxis|
|cellular response to ATP|
|negative regulation of bone mineralization|
|dendritic cell migration|
|positive regulation of heart rate|
|cell-cell signaling involved in cardiac conduction|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|regulation of cardiac muscle cell action potential|
|membrane depolarization during action potential|
|regulation of T cell cytokine production|
|response to ATP|
|vasoconstriction|
|positive regulation of vasoconstriction|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of heart rate by cardiac conduction|
|positive regulation of heart contraction|
|regulation of cardiac muscle cell contraction|
|negative regulation of blood vessel diameter|
|regulation of actin filament-based movement|
|negative regulation of osteoblast differentiation|
|cell communication involved in cardiac conduction|
|regulation of membrane depolarization|
|positive regulation of muscle contraction|
|regulation of action potential|
|cardiac muscle cell action potential|
|membrane depolarization|
|calcium channel activity|
|regulation of vasoconstriction|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of fat cell differentiation|
|protein sumoylation|
|cellular response to nutrient|
|regulation of cardiac conduction|
|regulation of T cell mediated immunity|
|positive regulation of blood circulation|
|positive regulation of insulin secretion|
|negative regulation of ossification|
|regulation of bone mineralization|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of cardiac muscle contraction|
|regulation of cytokine production involved in immune response|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|regulation of biomineral tissue development|
|cardiac conduction|
|protein homotetramerization|
|regulation of biomineralization|
|action potential|
|import across plasma membrane|
|positive regulation of peptide hormone secretion|
|regulation of heart rate|
|regulation of osteoblast differentiation|
|regulation of fat cell differentiation|
|positive regulation of hormone secretion|
|multicellular organismal signaling|
|response to organophosphorus|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of production of molecular mediator of immune response|
|positive regulation of canonical Wnt signaling pathway|
|leukocyte chemotaxis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|calcium-mediated signaling|
|protein tetramerization|
|regulation of lymphocyte mediated immunity|
|response to purine-containing compound|
|sodium ion transport|
|regulation of muscle contraction|
|regulation of adaptive immune response|
|vascular process in circulatory system|
|positive regulation of Wnt signaling pathway|
|regulation of insulin secretion|
|regulation of ossification|
|calcium ion transmembrane transport|
|calmodulin binding|
|regulation of leukocyte mediated immunity|
|regulation of peptide hormone secretion|
|cell chemotaxis|
|response to nutrient|
|cellular response to nutrient levels|
|regulation of muscle system process|
|regulation of heart contraction|
|calcium ion transport|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of canonical Wnt signaling pathway|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|divalent inorganic cation transport|
|peptidyl-lysine modification|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|protein homooligomerization|
|regulation of Wnt signaling pathway|
|neuronal cell body|
|leukocyte migration|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|cellular response to drug|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to nutrient levels|
|regulation of anatomical structure size|
|protein complex oligomerization|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|adaptive immune response|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|regulation of cytokine production|
|regulation of protein transport|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|ion transmembrane transport|
|cell migration|
|positive regulation of cell differentiation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.67|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.36|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.3|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.06|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.89|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.79|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.73|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.71|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14182
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPM4 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>