======= TRUB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRUB2
  * **<color #00a2e8>Official Name</color>**: TruB pseudouridine synthase family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26995|26995]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95900|O95900]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRUB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRUB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610727|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Minor enzyme contributing to the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability. {ECO:0000269|PubMed:27974379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TruB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudouridine synthase activity|
|positive regulation of mitochondrial translation|
|pseudouridine synthesis|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|RNA modification|
|regulation of translation|
|mitochondrial matrix|
|regulation of cellular amide metabolic process|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.96|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.7|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.71|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.72|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.79|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.82|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.92|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.95|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.95|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.01|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.05|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.09|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.12|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.27|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.56|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.637|
|[[:human genes:m:mrp63|MRP63]]|0.613|
|[[:human genes:m:mrps34|MRPS34]]|0.612|
|[[:human genes:y:yars2|YARS2]]|0.612|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.608|
|[[:human genes:m:mrps12|MRPS12]]|0.598|
|[[:human genes:m:mrps18a|MRPS18A]]|0.593|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.592|
|[[:human genes:m:mrps16|MRPS16]]|0.59|
|[[:human genes:m:mrps6|MRPS6]]|0.588|
|[[:human genes:m:mrpl23|MRPL23]]|0.583|
|[[:human genes:m:mrps21|MRPS21]]|0.58|
|[[:human genes:m:mtpap|MTPAP]]|0.568|
|[[:human genes:q:qrsl1|QRSL1]]|0.563|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.563|
|[[:human genes:v:vars2|VARS2]]|0.56|
|[[:human genes:m:mrpl55|MRPL55]]|0.554|
|[[:human genes:m:mrps35|MRPS35]]|0.553|
|[[:human genes:r:rpusd4|RPUSD4]]|0.553|
|[[:human genes:m:mrps25|MRPS25]]|0.553|
|[[:human genes:m:mrps14|MRPS14]]|0.551|
|[[:human genes:d:dars2|DARS2]]|0.55|
|[[:human genes:m:mrpl47|MRPL47]]|0.547|
|[[:human genes:m:mrps5|MRPS5]]|0.546|
|[[:human genes:f:fastkd5|FASTKD5]]|0.544|
|[[:human genes:r:rars2|RARS2]]|0.543|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.54|
|[[:human genes:p:pnpt1|PNPT1]]|0.54|
|[[:human genes:n:ndufa3|NDUFA3]]|0.538|
|[[:human genes:h:hars2|HARS2]]|0.535|
|[[:human genes:c:cox16|COX16]]|0.533|
|[[:human genes:s:selrc1|SELRC1]]|0.533|
|[[:human genes:m:mrpl3|MRPL3]]|0.533|
|[[:human genes:f:fars2|FARS2]]|0.532|
|[[:human genes:m:mrps26|MRPS26]]|0.53|
|[[:human genes:n:nars2|NARS2]]|0.528|
|[[:human genes:t:tufm|TUFM]]|0.524|
|[[:human genes:m:mrps9|MRPS9]]|0.523|
|[[:human genes:p:ptcd3|PTCD3]]|0.522|
|[[:human genes:s:sars2|SARS2]]|0.521|
|[[:human genes:d:dap3|DAP3]]|0.519|
|[[:human genes:c:c10orf2|C10orf2]]|0.519|
|[[:human genes:s:sco2|SCO2]]|0.516|
|[[:human genes:n:ndufb11|NDUFB11]]|0.516|
|[[:human genes:n:ndufv1|NDUFV1]]|0.515|
|[[:human genes:p:pet112|PET112]]|0.515|
|[[:human genes:t:tars2|TARS2]]|0.514|
|[[:human genes:g:gfm1|GFM1]]|0.512|
|[[:human genes:f:ftsj2|FTSJ2]]|0.512|
|[[:human genes:m:mars2|MARS2]]|0.51|
|[[:human genes:p:pars2|PARS2]]|0.509|
|[[:human genes:n:ndufa1|NDUFA1]]|0.509|
|[[:human genes:d:ddx28|DDX28]]|0.506|
|[[:human genes:l:lars2|LARS2]]|0.506|
|[[:human genes:m:mrpl33|MRPL33]]|0.503|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.501|
|[[:human genes:m:mrpl52|MRPL52]]|0.499|
|[[:human genes:m:mrpl18|MRPL18]]|0.498|
|[[:human genes:c:cox7b|COX7B]]|0.498|
|[[:human genes:r:rbfa|RBFA]]|0.497|
|[[:human genes:t:tfam|TFAM]]|0.496|
|[[:human genes:c:cox6b1|COX6B1]]|0.494|
|[[:human genes:m:mtg2|MTG2]]|0.493|
|[[:human genes:u:uqcr10|UQCR10]]|0.492|
|[[:human genes:c:coa3|COA3]]|0.491|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.49|
|[[:human genes:m:mrps2|MRPS2]]|0.49|
|[[:human genes:m:mrpl42|MRPL42]]|0.489|
|[[:human genes:g:gfm2|GFM2]]|0.488|
|[[:human genes:m:mrpl45|MRPL45]]|0.486|
|[[:human genes:m:mrps22|MRPS22]]|0.485|
|[[:human genes:c:clpp|CLPP]]|0.485|
|[[:human genes:e:ears2|EARS2]]|0.482|
|[[:human genes:m:mrpl12|MRPL12]]|0.481|
|[[:human genes:r:rpusd3|RPUSD3]]|0.481|
|[[:human genes:m:mrps10|MRPS10]]|0.48|
|[[:human genes:m:mrpl20|MRPL20]]|0.48|
|[[:human genes:m:mrps24|MRPS24]]|0.479|
|[[:human genes:c:c12orf65|C12orf65]]|0.479|
|[[:human genes:m:mrpl44|MRPL44]]|0.476|
|[[:human genes:t:tefm|TEFM]]|0.474|
|[[:human genes:m:mrps23|MRPS23]]|0.471|
|[[:human genes:m:mrpl39|MRPL39]]|0.471|
|[[:human genes:n:ndufc2|NDUFC2]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.468|
|[[:human genes:a:acad9|ACAD9]]|0.468|
|[[:human genes:m:mrps7|MRPS7]]|0.466|
|[[:human genes:m:mettl17|METTL17]]|0.465|
|[[:human genes:m:mrpl53|MRPL53]]|0.464|
|[[:human genes:l:lrpprc|LRPPRC]]|0.463|
|[[:human genes:w:wbscr16|WBSCR16]]|0.462|
|[[:human genes:g:gatc|GATC]]|0.462|
|[[:human genes:s:slc25a26|SLC25A26]]|0.461|
|[[:human genes:a:atp5d|ATP5D]]|0.46|
|[[:human genes:c:cars2|CARS2]]|0.46|
|[[:human genes:p:pdss1|PDSS1]]|0.458|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.457|
|[[:human genes:c:c17orf89|C17orf89]]|0.457|
|[[:human genes:a:aars2|AARS2]]|0.456|
|[[:human genes:t:tomm20|TOMM20]]|0.454|
|[[:human genes:m:mrpl41|MRPL41]]|0.453|
|[[:human genes:b:bcs1l|BCS1L]]|0.452|
|[[:human genes:n:ndufb9|NDUFB9]]|0.452|
|[[:human genes:m:mrpl4|MRPL4]]|0.449|
|[[:human genes:c:cox15|COX15]]|0.449|
|[[:human genes:m:mrpl46|MRPL46]]|0.449|
|[[:human genes:m:mrpl13|MRPL13]]|0.447|
|[[:human genes:p:pet117|PET117]]|0.446|
|[[:human genes:m:mrpl17|MRPL17]]|0.446|
|[[:human genes:t:trmt10c|TRMT10C]]|0.446|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.443|
|[[:human genes:e:ecsit|ECSIT]]|0.442|
|[[:human genes:m:mterfd2|MTERFD2]]|0.442|
|[[:human genes:w:wars2|WARS2]]|0.442|
|[[:human genes:m:mrpl34|MRPL34]]|0.442|
|[[:human genes:m:mipep|MIPEP]]|0.442|
|[[:human genes:m:mrpl43|MRPL43]]|0.441|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.441|
|[[:human genes:m:mtg1|MTG1]]|0.441|
|[[:human genes:m:mterfd1|MTERFD1]]|0.439|
|[[:human genes:n:ndufb6|NDUFB6]]|0.437|
|[[:human genes:m:mrps27|MRPS27]]|0.436|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.436|
|[[:human genes:c:coa6|COA6]]|0.435|
|[[:human genes:m:mrpl51|MRPL51]]|0.432|
|[[:human genes:c:coq3|COQ3]]|0.431|
|[[:human genes:m:mrpl36|MRPL36]]|0.431|
|[[:human genes:p:polrmt|POLRMT]]|0.431|
|[[:human genes:m:malsu1|MALSU1]]|0.43|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.429|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.429|
|[[:human genes:t:tfb2m|TFB2M]]|0.428|
|[[:human genes:c:coa5|COA5]]|0.427|
|[[:human genes:t:tomm40|TOMM40]]|0.425|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.425|
|[[:human genes:a:aifm1|AIFM1]]|0.424|
|[[:human genes:n:ndufs2|NDUFS2]]|0.422|
|[[:human genes:m:mrpl49|MRPL49]]|0.422|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.421|
|[[:human genes:n:ndufs8|NDUFS8]]|0.42|
|[[:human genes:t:timm8b|TIMM8B]]|0.42|
|[[:human genes:m:mtif2|MTIF2]]|0.419|
|[[:human genes:m:mrpl37|MRPL37]]|0.419|
|[[:human genes:m:mrps17|MRPS17]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.415|
|[[:human genes:m:mrpl22|MRPL22]]|0.414|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.412|
|[[:human genes:n:ndufa2|NDUFA2]]|0.411|
|[[:human genes:f:fastkd2|FASTKD2]]|0.41|
|[[:human genes:c:coq2|COQ2]]|0.409|
|[[:human genes:n:ndufc1|NDUFC1]]|0.408|
|[[:human genes:o:opa1|OPA1]]|0.406|
|[[:human genes:n:ndufa6|NDUFA6]]|0.405|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.404|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.403|
|[[:human genes:n:ndufb5|NDUFB5]]|0.403|
|[[:human genes:n:ndufa11|NDUFA11]]|0.403|
|[[:human genes:c:cox6c|COX6C]]|0.401|
|[[:human genes:g:glrx5|GLRX5]]|0.401|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.4|
|[[:human genes:a:atp5a1|ATP5A1]]|0.4|
|[[:human genes:m:mrpl2|MRPL2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 454
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRUB2 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>